Percorrer por autor "Tendeiro, Rita"
A mostrar 1 - 2 de 2
Resultados por página
Opções de ordenação
- Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cellsPublication . Rocha, Cheila; Duarte, Joana; Borrego, Pedro; Calado, Rita; Marcelino, José Maria; Tendeiro, Rita; Valadas, Emília; Sousa, Ana Espada; Taveira, NunoPotent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.
- Shaping the founders : naïve CD4 T cell heterogeneity in people with HIV-1 or HIV-2Publication . Badura, Robert; Martins, Nicole C.; Farias, Guilherme B.; Tendeiro, Rita; Foxall, Russell B.; Santos, Diana F.; Gomes, André M. C.; Marques, Rita T.; Moleirinho, Beatriz; Godinho-Santos, Ana C.; Valadas, Emília; Gomes, Perpétua; Almeida, Afonso R. M.; Sousa, Ana E.Naïve CD4 T cells harbour functional subsets that influence the quality of immune reconstitution and the persistent viral reservoirs in people with HIV (PWH) under antiretroviral therapy (ART). Here, we profiled the circulating naïve CD4 T cells from PWH under effective ART with distinct past histories of viral burden, namely starting treatment early in acute or late in chronic stage HIV-1 infection, and people with HIV-2 (PWH2), who feature low to undetectable viremia before ART and slow disease progression. Spectral flow cytometry enabled us to capture the heterogeneity of this overlooked T cell compartment. Early-treated PWH1 maintained a naïve CD4 T cell profile comparable to that of age-matched seronegative individuals. Late-treated PWH1 and PWH2 showed distinct imbalances in conventional and regulatory subpopulations, yet both exhibited a relative expansion of CD31-expressing naïve cells, consistent with an IL-7-mediated homeostatic response. The ability of purified naïve CD4 T cells to respond to IL-7 was evaluated in additional cohorts of untreated PWH, revealing reduced proliferation and increased p21 transcription in PWH1 elite controllers. Additionally, a significant decline in proviral DNA was found in PWH2, suggesting an impact of IL-7 on HIV-2-infected naïve CD4 T cells that was not observed in the case of HIV-1 infection. Unravelling the homeostatic pathways and functional implications of naïve CD4 T cell heterogeneity will help clarify viral reservoir dynamics and inflammation in PWH and define strategies to prevent immune senescence.