Percorrer por autor "Su, Naichuan"
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- External validation of periodontal screening using self-reports in dental settingsPublication . Viana, João; Machado, Vanessa; Lyra, Patrícia; Proença, Luís; Su, Naichuan; Mendes, José João; Botelho, JoãoBackground/Objectives: This study aimed to externally validate the screening model for severe PD proposed by Verhulst in a Portuguese population, assessing its discriminative performance and clinical applicability. Methods: A cross-sectional study was conducted with 310 adults recruited from a university dental clinic in Portugal. The participants completed a validated self-reported oral health questionnaire (screening model) and underwent a full-mouth periodontal examination using the CPITN index, with severe PD defined as a score of 4. Model performance was evaluated for discrimination, calibration, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Results: Of the 310 participants, 51% were diagnosed with severe PD. The Verhulst model showed an area under the curve (AUC) of 0.72 (95% CI: 0.67–0.77), with sensitivity and specificity of 0.709 (95% CI: 0.639–0.779) and 0.724 (95% CI: 0.651–0.796) and PPV and NPV of 0.727 (95% CI: 0.673–0.784) and 0.704 (95% CI: 0.651–0.764), respectively. Calibration was reasonable, with an observed-to-expected ratio of 1.10 (95% CI: 0.939–1.291). Conclusions: The model demonstrated acceptable external validity and could serve as a feasible screening tool for severe PD in Portuguese dental settings. Its integration may enhance early diagnosis and interdisciplinary care. Future studies should consider broader diagnostic criteria to refine accuracy.
- Neutrophils at the crossroads of oral microbiome dysbiosis and periodontal diseasePublication . Viana, João; Ferro, Tiago; Pitschieller, Ricardo; Machado, Vanessa; Su, Naichuan; Mendes, José João; Botelho, JoãoNeutrophils are the most abundant circulating leukocytes and essential components of innate immunity. Through mechanisms such as phagocytosis, reactive oxygen species (ROS) production, degranulation, and neutrophil extracellular trap (NET) formation, they play a crucial role in host defense. However, dysregulated neutrophil responses are linked to chronic inflammatory conditions, including periodontitis. This review summarizes current evidence on neutrophil biology in periodontal health and disease, focusing on functional mechanisms, recruitment pathways, the influence of dysbiosis, and their potential as biomarkers and therapeutic targets. Neutrophils display a dual role in periodontal tissues: while protecting against microbial invasion, their excessive or impaired activity contributes to tissue destruction. Altered chemotaxis, defective phagocytosis, and uncontrolled NET release perpetuate inflammation and alveolar bone loss. Neutrophil-derived enzymes, including myeloperoxidase, elastase, and matrix metalloproteinases, emerge as promising biomarkers for early diagnosis. In parallel, therapeutic strategies targeting oxidative stress, NET regulation, or neutrophil hyperactivity are being explored to preserve periodontal tissues. Neutrophils are central players in periodontal pathophysiology. Understanding their regulation and interaction with the oral microbiome may enable the development of novel diagnostic and therapeutic approaches, ultimately improving periodontal disease management.