Browsing by Author "Soares, Maria"
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- Brincar hojePublication . Soares, Maria; Aston, JeremyBrincar hoje é um tema que poderá não estar tão distante do passado como o previsto. As tecnologias e inovações apresentadas num ritmo cada vez mais acelerado são abraçadas pelas crianças de uma forma natural e espontânea. No entanto, a Criança de hoje nasce com as mesmas necessidades primárias das dos séculos passados e assim como estas, o seu desenvolvimento saudável ainda implica correr, saltar, manipular objectos, estimular os sentidos e a socialização. Este documento relata o meu contributo direto na criação, desenvolvimento e lançamento comercial de uma marca - a elou cork toys, com a sua primeira coleção de brinquedos de cortiça. O projeto, com a orientação criativa da esad - idea, insere-se num contexto de estágio onde a aprendizagem se funde com um ambiente profissional em que a inter-relação com os parceiro industriais é crucial para uma conclusão do briefing, passando pela reunião e organização da informação dos temas apropriados e indispensáveis para uma base sólida de criação, até à conceção dos conceitos e concretização dos brinquedos finais. Também é descrita para cada peça através do esclarecimento junto dos produtores ou através da tentativa-erro no caso de peças dúbias. O relatório é concluido com a apresentação dos brinquedos em feiras internacionais e feedback do mercado.
- fHER2, PR, ER, Ki-67 and cytokeratin 5/6 expression in benign feline mammary lesionsPublication . Soares, Maria; Correia, Assunção N.; Batista, Mariana R.; Correia, Jorge; Ferreira, FernandoBiomarkers are essential in the characterization of neoplastic lesions and aid not only in the classification of the nature of the lesions, but also in the understanding of their ontogeny, development and prognosis. In cats, while mammary carcinomas are increasingly being characterized, information on their benign lesions is still scarce. Indeed, a better characterization of benign lesions could have an important role in unravelling mammary oncogenesis, similar to that in human breast cancer. Thus, in this study, the expression of five markers was analyzed in 47 benign mammary lesions (hyperplasia, dysplasia and benign tumors) collected from 27 queens. Dysplastic and hyperplastic lesions were the most common (41/47, 81.7%). Most of the lesions were classified as ER positive (43/47, 91.5%), PR negative (30/47, 63.8%), fHER2 negative (29/47, 64.4%), CK 5/6 negative (36/47, 76.6%) and with a low Ki-67 index (37/47, 78.7%). Statistical analysis revealed a correlation between younger ages and ER positivity (p = 0.013) and between larger lesions and negative PR status (p = 0.038). These results reinforce the importance of evaluating the expression of the ER status, prevalent in benign lesions, as a putative precursor in cancer progression.
- Laboratory Assessment of the Effects of AGA@4life Multidisciplinary Intervention on the Inflammatory Profile, MMPs, and TIMPs in a Geriatric PopulationPublication . Lourenço, Ana Patrícia; Freitas, Catarina; Timóteo, Maria Helena; Soares, Maria; Figueiredo, João; Osório, Nádia; Valado, Ana; Trapali, Maria; Pereira, Telmo; Caseiro, ArmandoAbstract: In recent years, the world’s aging population has increased, contributing to the development of age-related pathologies, which have been aggravated by physical inactivity and excessive fat intake. This study aimed to evaluate the effect of implementing a nutritional program (control group—CG) combined with exercise (intervention group—IG) on the inflammatory profile, MMPs, and TIMPs in a group of 34 elderly participants (IG, n = 18; CG, n = 16). Participants underwent a full multidisciplinary diagnostic evaluation (T0), with the gathering of clinical information and biochemical and hematological determinations being re-evaluated eight weeks later (T1). A diet manual was made, which provided a selection of different types of diets resulting from the nutritional needs of the different users at the center. The aerobic exercise consisted of two sessions per week with a total duration of 1 h. The laboratory evaluation was performed by slot blot. Statistical analysis included a paired sample t-test and Spearman’s correlation coefficient. We observed that in the IG, there was a significant increase at T1 of TNF-α (p < 0.05) and MMP-2 (p < 0.05), without changes in IL-6 and MMP-9, showing that the intervention did not cause an exacerbated inflammatory response in exercised elderly people. The intervention program implemented showed potential to contribute to better active aging strategies, taking advantage of the known benefits of exercise without inducing a harmful inflammatory response in elderly participants.