Browsing by Author "Silva, MI"
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- Neurolymphomatosis as primary presentation of extra-nodal NK/T-cell lymphoma, nasal typePublication . Silva, MI; Santos, P; Viegas, D; Miranda, M; Montes, V; Pita, F; Carmona, CNeurolymphomatosis (NL) describes an infiltration of cranial and peripheral nerves by lymphoma cells, most frequently in non-Hodgkin B-cell lymphoma. This clinical entity is rare and poses a challenging diagnosis. We describe a case of a 64-year-old female patient with NL associated with extra-nodal NK/T-cell lymphoma (ENKTL), nasal type, presenting as a painful progressive mononeuropathy multiplex with an oral cavity lesion. ENKTL is usually associated with Epstein-Barr virus (EBV) infection and rarely affects the central and peripheral nervous system. Lumbar puncture, magnetic resonance imaging (MRI), nerve biopsy, and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) help to establish the diagnosis. Thereby, NL should be considered in the differential diagnosis of painful progressive multiple neuropathies, even in patients without previous history of cancer.
- Recurrent optic neuropathy: a case of Harding’s disease?Publication . Miranda, M; Andrade, MM; Silva, MI; Sousa, SC; Carmona, C