Browsing by Author "Santos, Inês A."
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- 3D-Printing of paracetamol tablets by fused deposition modellingPublication . Pereira, Gabriela G.; Henriques, Ana I.; Fernandes, A.I.; Santos, Inês A.; Pinto, João F.
- 3D-Printing of paracetamol tablets by fused deposition modellingPublication . Pereira, Gabriela G.; Henriques, Ana I.; Fernandes, A.I.; Santos, Inês A.; Pinto, João F.
- Characterization and stability of co-amorphous systems containing Olanzapine and sulfonic acidsPublication . Santos, Inês A.; Bastos, Ana C.; Pinto, João F.; Fernandes, Ana I.
- Co-formability, solubility enhancement and stability of Olanzapine co-amorphous systems produced with different co-formersPublication . Bastos, Ana C.; Santos, Inês A.; Pinto, João F.; Fernandes, Ana I.
- Co-formability, solubility enhancement and stability of Olanzapine co-amorphous systems produced with different co-formersPublication . Bastos, Ana C.; Santos, Inês A.; Pinto, João F.; Fernandes, Ana I.
- Study of the stability of acetaminophen extrudates for 3D printing prepared by hot melt extrusion when stored at different relative humiditesPublication . Pereira, Gabriela G.; Henriques, Ana I.; Fernandes, Ana I.; Santos, Inês A.; Pinto, João F.
- Sulfonic acid derivatives in the production of stable co-amorphous systems for solubility enhancementPublication . Costa, Nuno F. da; Santos, Inês A.; Fernandes, Ana I.; Pinto, João F."Co-amorphization is a promising approach to stabilize drugs in the amorphous form. Olanzapine, a poorly water-soluble drug was used in this study. Sulfonic acids (saccharin, cyclamic acid and acesulfame), free and in salt forms, were used as co-formers and compared with carboxylic acids commonly used in the preparation of co-amorphous systems. Several manufacturing techniques were tested, and the co-amorphous systems characterized by differential scanning calorimetry, X-ray powder diffraction, thermogravimetry and Fourier-transform infrared spectroscopy. Free sulfonic acids produced co-amorphous systems with the drug, unlike their salts. Spectroscopy data suggests the formation of salts between olanzapine and the sulfonic acids, used as co-formers. The co-amorphous system produced with saccharin by solvent evaporation, showed the most notable solubility enhancement (145 times). The stability of amorphous and co-amorphous olanzapine systems was assessed upon exposure to stress conditions during storage. Amorphized olanzapine readily reconverted back to the crystalline form while sulfonic acids:olanzapine co-amorphous were stable for up to 24 weeks in low/medium humidity conditions (11-75% RH). Results highlight the potential advantages offered by sulfonic acids as co-formers to produce stable and more soluble co-amorphous olanzapine."