Browsing by Author "Rocha, Susana"
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- Effects of statins therapy on LDL subfractions and inflammation in end-stage renal disease patients on dialysisPublication . Coimbra, Susana; Reis, Flávio; Nunes, Sara; Viana, Sofia; Valente, Maria João; Rocha, Susana; Catarino, Cristina; Rocha-Pereira, Petronila; Bronze-da-Rocha, Elsa; Oliveira, José Gerardo; Madureira, José; Fernandes, João Carlos; Do Sameiro-Faria, Maria; Miranda, Vasco; Belo, Luís; Santos-Silva, Alice
- Modelo de formação das praças em regime de contrato: novas abordagens rumo à qualificaçãoPublication . Rocha, SusanaO modelo de profissionalização do serviço militar exige uma procura contínua de estratégias que permitam contribuir para atrair, recrutar e reter os militares, bem como garantir as condições adequadas à sua reinserção profissional. Assumindo a formação um papel essencial e prioritário neste contexto, emerge a necessidade permanente de avaliar e rever os modelos de formação e de carreira nas Forças Armadas, antecipando-se e projetando-se possibilidades que se traduzam em abordagens adequadas e eficientes, alinhadas com as políticas nacionais e com o Sistema Nacional de Qualificações (SNQ). Partindo de um paradigma de investigação em Educação de natureza pragmática, o presente estudo desenvolve-se de acordo com a tipologia de investigação Design-Based Research (DBR), visando propor um modelo de formação das praças em regime de contrato (RC) da Marinha Portuguesa que garanta a elevação das suas qualificações. Através de uma abordagem que contempla três grandes fases (Análise/Exploração, Design/Conceção, Avaliação/Reflexão), com sucessivas etapas e ciclos de exploração e análise, foi possível conceber e validar um modelo de formação das praças em RC da Marinha que garanta a elevação das qualificações. Abstract: The professionalization model of the military service requires a continuous search for strategies that help to attract, recruit and retain the military, as well as guarantee the appropriate conditions for their professional reintegration. As education and training plays an essential and priority role in this context, there is a permanent need to evaluate and review training and career models in the Armed Forces, anticipating and projecting possibilities that translate into adequate and efficient approaches, in line with the national policies and with the National Qualifications System (SNQ). Starting from a pragmatic research paradigm in Education, the present study is developed according to the Design-Based Research (DBR) investigation typology, aiming to propose an educational and training model for the Portuguese Navy's enlisted on contract regime (RC) that guarantees the elevation of their qualifications. Through an approach that includes three major phases (Analysis/Exploration, Design/Construction, Evaluation/Reflection), with successive stages and cycles of exploration and analysis, it was possible to design and validate an educational and training model for the formation of the Navy’s enlisted on RC granting to raise their qualifications.
- The protective role of adiponectin for lipoproteins in end-stage renal disease patients: relationship with diabetes and body mass indexPublication . Coimbra, Susana; Reis, Flávio; Nunes, Sara; Viana, Sofia; Valente, Maria João; Rocha, Susana; Catarino, Cristina; Rocha-Pereira, Petronila; Bronze-da-Rocha, Elsa; Sameiro-Faria, Maria; Oliveira, José Gerardo; Madureira, José; Fernandes, João Carlos; Miranda, Vasco; Belo, Luís; Santos-Silva, AliceCardiovascular disease (CVD) events are the main causes of death in end-stage renal disease (ESRD) patients on dialysis. The number and severity of CVD events remain inappropriate and difficult to explain by considering only the classic CVD risk factors. Our aim was to clarify the changes and the relationship of lipoprotein subfractions with other CVD risk factors, namely, body mass index (BMI) and adipokines, inflammation and low-density lipoprotein (LDL) oxidation, and the burden of the most prevalent comorbidities, diabetes mellitus (DM) and hypertension (HT). We studied 194 ESRD patients on dialysis and 22 controls; lipid profile, including lipoprotein subpopulations and oxidized LDL (oxLDL), C-reactive protein (CRP), adiponectin, leptin, and paraoxonase 1 activity were evaluated. Compared to controls, patients presented significantly lower levels of cholesterol, high-density lipoprotein cholesterol (HDLc), LDLc, oxLDL, and intermediate and small HDL and higher triglycerides, CRP, adiponectin, large HDL, very-low-density lipoprotein (VLDL), and intermediate-density lipoprotein- (IDL) B. Adiponectin levels correlated positively with large HDL and negatively with intermediate and small HDL, oxLDL/LDLc, and BMI; patients with DM (n = 17) and with DM+HT (n = 70), as compared to patients without DM or HT (n = 69) or only with HT (n = 38), presented significantly higher oxLDL, oxLDL/LDLc, and leptin and lower adiponectin. Obese patients (n = 45), as compared to normoponderal patients (n = 81), showed lower HDLc, adiponectin, and large HDL and significantly higher leptin, VLDL, and intermediate and small HDL. In ESRD, the higher adiponectin seems to favor atheroprotective HDL modifications and protect LDL particles from oxidative atherogenic changes. However, in diabetic and obese patients, adiponectin presents the lowest values, oxLDL/LDLc present the highest ones, and the HDL profile is the more atherogenic. Our data suggest that the coexistence of DM and adiposity in ESRD patients on dialysis contributes to a higher CVD risk, as showed by their lipid and adipokine profiles.