Percorrer por autor "Pires, Ana"
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- Characterization of Antidepressant Consumption in a Portuguese Inland Population.Publication . Soares, Sofia; Rosado, Tiago; Santos, Vítor Hugo; Rei, Cristina; Amantegui, Patricia; Pissarra da Costa, António; Chaves, Telma; Valente, Rita; Duarte, Fábio; Pacheco, Susana; Martins, Marco; Dias, Kátia; Costa, Patricia; Costa, Rui; Castro, Sílvia; Sousa, Diana; Figueiredo, Diana; Soares, Isabel; Mouta, Salomé; Jesus, Bianca; Pires, Ana; Ribeiro, Cândida; Lobo, Sónia; Correia, Leonor; Malés, Sofia; Vale, Fátima; Moita, Carina; Moura, Carolina; Sousa, Joana; Afonso, Luís Rafael; Costa, Rita Santinho; Barroso, Mário; Gallardo, EugeniaMental disorders are a growing global concern, with depression being among the most prevalent. Portugal ranks second in antidepressant consumption within the OECD, following a threefold increase between 2000 and 2020. In inland regions such as Beira Interior, reduced healthcare services and distance from major hospitals further complicate access to care. This study analysed 142 patients from Beira Interior undergoing antidepressant therapy to characterise their demographic and clinical profile and to assess associations with adverse effects. A cross-sectional survey collected demographic data, clinical diagnoses, prescribed antidepressants, concomitant medications, and reported adverse effects. Both descriptive and inferential statistical analyses were performed. Most participants were female (81.0%), with a mean age of 57.8 years. Major depression was the most common diagnosis (76.1%). Selective serotonin reuptake inhibitors (47.4%) and trazodone (27.8%) were the most prescribed agents. Treatment had lasted one to five years in 59.9% of cases. Concomitant use of benzodiazepines (76.8%) and antipsychotics (48.6%) was frequent. Reported adverse effects included anticholinergic symptoms (38.7%) and confusion/agitation (26.8%). Women were more likely to use serotonin modulators, while patients >64 years had higher odds of using tetracyclic/unicyclic antidepressants, serotonin modulators, and multiple antidepressants. These classes were significantly associated with increased adverse effects. The findings reveal important risks related to polypragmasia and adverse reactions, underscoring the need for individualised prescribing, rigorous monitoring, and strict adherence to guidelines. Larger, stratified, and longitudinal studies are needed to clarify causality and optimise treatment outcomes.
- Chromatographic determination of antidepressants in plasma and saliva: Towards non-invasive therapeutic monitoringPublication . Soares, Sofia; Rosendo, Luana; Fonseca, Suzana; Gonçalves, Nuno; Franco, João; da Costa, António Pissarra; Rosado, Tiago; Barroso, Mário; Santos, Vítor Hugo; Rei, Cristina; Amantegui, Patricia; Chaves, Telma; Valente, Rita; Duarte, Fábio; Pacheco, Susana; Martins, Marco; Dias, Kátia; Costa, Patricia; Costa, Rui; Castro, Sílvia; Sousa, Diana; Figueiredo, Diana; Soares, Isabel; Mouta, Salomé; Jesus, Bianca; Pires, Ana; Ribeiro, Cândida; Lobo, Sónia; Correia, Leonor; Malés, Sofia; Vale, Fátima; Moita, Carina; Moura, Carolina; Sousa, Joana; Afonso, Luís Rafael; Costa, Rita Santinho; Gallardo, EugeniaDrug monitoring of antidepressants in plasma and oral fluid represents a valuable tool in clinical practice, enabling the optimisation of treatment efficacy and the reduction of adverse effects. Given the significant interindividual variability in antidepressant response-driven by factors such as metabolism, drug-drug interactions, and adherence to therapy-drug monitoring facilitates dose adjustment based on measured drug concentrations, ensuring levels remain within the therapeutic window. This study aimed at developing and validating a robust, rapid, and sensitive method for the simultaneous quantification of 21 selected antidepressants and their metabolites in only 100 μL of plasma and oral fluid. Sample preparation was performed using a simple protein precipitation protocol, followed by analysis via liquid chromatography-tandem mass spectrometry (LC-MS/MS). The method was validated in accordance with internationally accepted bioanalytical guidelines, demonstrating linearity over the concentration range of 0.98-1000 ng/mL. Limits of quantification were established at 0.98 ng/mL for all analytes across both matrices. The extraction procedure yielded high recovery rates, and the method showed excellent selectivity, sensitivity, precision, and accuracy, confirming its suitability for routine toxicological applications. The validated method was successfully applied to 142 paired authentic plasma and oral fluid specimens from patients undergoing antidepressant therapy. Antidepressant concentrations were determined in both matrices, and treatment adherence was considered high, being confirmed in 88.7 % of patients. Correlation analysis between plasma and oral fluid concentrations produced promising results for several of the compounds under investigation, reinforcing the potential utility of oral fluid as a non-invasive alternative matrix in drug monitoring.
- As crenças sobre a violência conjugal em católicos e não católicosPublication . Sacramento, Ana; Pires, Ana; Guarda, Renata; Almeida, Iris; Neves, Cristina
- Debilidad muscular en pacientes críticos: efectos de un programa de rehabilitación sistematizado de enfermeríaPublication . Azevedo, Paulo; Gomes, Bárbara; Macedo, José; Ferreira, Soraia; Pereira, José; Pires, AnaObjetivo La debilidad adquirida en la unidad de cuidados intensivos (DAUCI) en pacientes críticos es frecuente, y se asocia a resultados negativos. La rehabilitación es una estrategia para mejorar los resultados. El propósito de este estudio fue evaluar los efectos de un programa de enfermería de rehabilitación al recibir el alta de la unidad de cuidados intensivos. Métodos Estudio cuasi-experimental, en el que se comparan pacientes que se sometieron a cuidados habituales de rehabilitación de enfermería y pacientes que se sometieron a un programa de enfermería de rehabilitación sistematizado. Muestra no probabilística secuencial de 42 pacientes críticos ventilados, 21 pacientes en el grupo de control y 21 pacientes en el grupo de intervención (de junio 2017 a junio 2019), en 3 unidades de cuidados intensivos de un gran hospital universitario portugués. Se realizó la prueba de Mann-Whitney para comparar los valores de la puntuación total del Medical Research Council Sum Score (MRC-SS) entre los grupos. Resultados Los pacientes que recibieron el programa de rehabilitación sistematizado, presentaron una disminución de la DAUCI en el momento del alta de la UCI (media de MRC-SS = 38 vs. media de MRC-SS = 42,7; p = 0,043; U = 152,5). Se produjo una disminución de la debilidad muscular severa (9,5 vs. 28,6%) y debilidad muscular significativa (42,9 vs. 52,4%) y un aumento de pacientes sin debilidad muscular (47,6 vs. 19%). Conclusiones El programa de enfermería de rehabilitación sistemática puede mejorar la fuerza muscular, y reducir la incapacidad funcional en el momento del alta de cuidados intensivos.