Browsing by Author "Pereira, Gabriela G."
Now showing 1 - 6 of 6
Results Per Page
Sort Options
- 3D-Printing of paracetamol tablets by fused deposition modellingPublication . Pereira, Gabriela G.; Henriques, Ana I.; Fernandes, A.I.; Santos, Inês A.; Pinto, João F.
- 3D-Printing of paracetamol tablets by fused deposition modellingPublication . Pereira, Gabriela G.; Henriques, Ana I.; Fernandes, A.I.; Santos, Inês A.; Pinto, João F.
- Evaluation of the stability of 3D-printed paracetamol tablets stored at different relative humiditiesPublication . Fernandes, Ana I.; Pereira, Gabriela G.; Santos, Inês; Pinto, João F.
- Influence of the infill geometry of 3D-printed tablets on drug dissolutionPublication . Venâncio, Nuno; Pereira, Gabriela G.; Pinto, João F.; Fernandes, Ana IsabelPatient-centric therapy is especially important in pediatrics and may be attained by three-dimensional printing. Filaments containing 30% w/w of theophylline were produced by hot-melt extrusion and printed using fused deposition modelling to produce tablets. Here, preliminary results evaluating the effect of infill geometry (cross, star, grid) on drug content and release are reported.
- Polymer selection for hot-melt extrusion coupled to fused deposition modelling in pharmaceuticsPublication . Pereira, Gabriela G.; Figueiredo, Sara; Fernandes, Ana Isabel; Pinto, João F.Three-dimensional (3D) printing offers the greatest potential to revolutionize the future of pharmaceutical manufacturing by overcoming challenges of conventional pharmaceutical operations and focusing design and production of dosage forms on the patient’s needs. Of the many technologies available, fusion deposition modelling (FDM) is considered of the lowest cost and higher reproducibility and accessibility, offering clear advantages in drug delivery. FDM requires in-house production of filaments of drug-containing thermoplastic polymers by hot-melt extrusion (HME), and the prospect of connecting the two technologies has been under investigation. The ability to integrate HME and FDM and predict and tailor the filaments’ properties will extend the range of printable polymers/formulations. Hence, this work revises the properties of the most common pharmaceutical-grade polymers used and their effect on extrudability, printability, and printing outcome, providing suitable processing windows for different raw materials. As a result, formulation selection will be more straightforward (considering the characteristics of drug and desired dosage form or release profile) and the processes setup will be more expedite (avoiding or mitigating typical processing issues), thus guaranteeing the success of both HME and FDM. Relevant techniques used to characterize filaments and 3D-printed dosage forms as an essential component for the evaluation of the quality output are also presented.
- Study of the stability of acetaminophen extrudates for 3D printing prepared by hot melt extrusion when stored at different relative humiditesPublication . Pereira, Gabriela G.; Henriques, Ana I.; Fernandes, Ana I.; Santos, Inês A.; Pinto, João F.