Browsing by Author "Oliveira, Andreia S."
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- Chemically crosslinked PVA hydrogels for cartilage substitutionPublication . Patacho, Inês; Oliveira, Andreia S.; Nolasco, Pedro; Colaço, Rogério; Serro, Ana P.
- Development of polycarbonate urethane-based materials with controlled diclofenac release for cartilage replacementPublication . Oliveira, Andreia S.; Ferreira, Inês; Branco, Ana C.; Silva, João C.; Costa, Carolina; Nolasco, Pedro; Marques, Ana C.; Silva, Diana; Colaço, Rogério; Figueiredo-Pina, Célio; Serro, Ana P.ydrogels are very promising human cartilage replacement materials since they are able to mimic its structure and properties. Besides, they can be used as platforms for drug delivery to reduce inflammatory postsurgical reactions. Polycarbonate urethane (PCU) has been used in orthopedic applications due to its long-term biocompatibility and bio-durability. In this work, PCU-based hydrogels with the ability to release an anti-inflammatory (diclofenac) were developed, for the first time, for such purpose. The materials were reinforced with different amounts of cellulose acetate (CA, 10%, 15%, and 25% w/w) or carbon nanotubes (CNT, 1% and 2% w/w) in order to improve their mechanical properties. Samples were characterized in terms of compressive and tensile mechanical behavior. It was found that 15% CA and 2% CNT reinforcement led to the best mechanical properties. Thus, these materials were further character- ized in terms of morphology, wettability, and friction coefficient (CoF). Contrarily to CNTs, the addition of CA significantly increased the material's porosity. Both mate- rials became more hydrophilic, and the CoF slightly increased for PCU + 15%CA. The materials were loaded by soaking with diclofenac, and drug release experiments were conducted. PCU, PCU + 15%CA and PCU + 2%CNT presented similar release pro- files, being able to ensure a controlled release of DFN for at least 4 days. Finally, in vitro cytotoxicity tests using human chondrocytes were also performed and con- firmed a high biocompatibility for the three studied materials.
- PVA-Based Hydrogels Loaded with Diclofenac for Cartilage ReplacementPublication . Branco, Ana C.; Oliveira, Andreia S.; Monteiro, Inês; Nolasco, Pedro; Silva, Diana C.; Figueiredo-Pina, Célio; Colaço, Rogério; Serro, Ana P.Polyvinyl alcohol (PVA) hydrogels have been widely studied for cartilage replacement due to their biocompatibility, chemical stability, and ability to be modified such that they approximate natural tissue behavior. Additionally, they may also be used with advantages as local drug delivery systems. However, their properties are not yet the most adequate for such applications. This work aimed to develop new PVA-based hydrogels for this purpose, displaying improved tribomechani- cal properties with the ability to control the release of diclofenac (DFN). Four types of PVA-based hydrogels were prepared via freeze-thawing: PVA, PVA/PAA (by polyacrylic acid (PAA) addition), PVA/PAA+PEG (by polyethylene glycol (PEG) immersion), and PVA/PAA+PEG+A (by annealing). Their morphology, water uptake, mechanical and rheological properties, wettability, friction coef- ficient, and drug release behavior were accessed. The irritability of the best-performing material was investigated. The results showed that the PAA addition increased the swelling and drug release amount. PEG immersion led to a more compact structure and significantly improved the material’s tribomechanical performance. The annealing treatment led to the material with the most suitable properties: besides presenting a low friction coefficient, it further enhanced the mechanical properties and ensured a controlled DFN release for at least 3 days. Moreover, it did not reveal irritability potential for biological tissues.