Development of polycarbonate urethane-based materials with controlled diclofenac release for cartilage replacement

Oliveira, Andreia S.; Ferreira, Inês; Branco, Ana C.; Silva, João C.; Costa, Carolina; Nolasco, Pedro; Marques, Ana C.; Silva, Diana; Colaço, Rogério; Figueiredo-Pina, Célio; Serro, Ana P.

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Authors

Figueiredo-Pina, Célio

Abstract(s)

ydrogels are very promising human cartilage replacement materials since they are able to mimic its structure and properties. Besides, they can be used as platforms for drug delivery to reduce inflammatory postsurgical reactions. Polycarbonate urethane (PCU) has been used in orthopedic applications due to its long-term biocompatibility and bio-durability. In this work, PCU-based hydrogels with the ability to release an anti-inflammatory (diclofenac) were developed, for the first time, for such purpose. The materials were reinforced with different amounts of cellulose acetate (CA, 10%, 15%, and 25% w/w) or carbon nanotubes (CNT, 1% and 2% w/w) in order to improve their mechanical properties. Samples were characterized in terms of compressive and tensile mechanical behavior. It was found that 15% CA and 2% CNT reinforcement led to the best mechanical properties. Thus, these materials were further character- ized in terms of morphology, wettability, and friction coefficient (CoF). Contrarily to CNTs, the addition of CA significantly increased the material's porosity. Both mate- rials became more hydrophilic, and the CoF slightly increased for PCU + 15%CA. The materials were loaded by soaking with diclofenac, and drug release experiments were conducted. PCU, PCU + 15%CA and PCU + 2%CNT presented similar release pro- files, being able to ensure a controlled release of DFN for at least 4 days. Finally, in vitro cytotoxicity tests using human chondrocytes were also performed and con- firmed a high biocompatibility for the three studied materials.

URI

http://hdl.handle.net/10400.26/50040

Citation

Oliveira, A. S., Ferreira, I., Branco, A. C., Silva, J. C., Costa, C., Nolasco, P., Marques, A. C., Silva, D., Colaço, R., Figueiredo-Pina, C. G., & Serro, A. P. (2022). Development of polycarbonate urethane-based materials with controlled diclofenac release for cartilage replacement. Journal of biomedical materials research. Part B, Applied biomaterials, 110(8), 1839–1852