Browsing by Author "Monteiro, L."
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- Industrial Automation Self-Learning Through the Develoment of Didactic Industrial ProcessesPublication . Cordeiro, A.; Abraços, M.; Monteiro, L.; Andrade, E.; Foito, Daniel José MedronhoTeaching industrial automation is a complex mission. The classical approach is based on lectures and laboratories assisted by teachers. Nevertheless, teaching industrial automation using the classical approach is not easy because this multidisciplinary area requires knowledge in control, energy, electronics, robotics and computer engineering, among others. In this way, this paper presents an approach to teach Industrial Automation based on a self learning strategy. Instead of using the classical approach, students must develop a research work and a didactic automation prototype. The results of this methodology indicate that students increase the interest about industrial automation and clarify important aspects of assembly, commissioning, parameterization and programming of electric and electronic devices. Additionally this methodology seems to increase self-confidence of students and give them the necessary background to face the challenge of working in the real world.
- Spectrum and frequency of gjb2 mutations in a cohort of 264 portuguese nonsyndromic sensorineural hearing loss patientsPublication . Matos, T. D.; Simões-Teixeira, H.; Caria, Helena; Gonçalves, A. C.; Chora, J.; Correia, M. C.; Moura, C.; Rosa, H.; Monteiro, L.; O'Neill, A.; Dias, O.; Andrea, M.; Fialho, G.Objective: To assess the spectrum and prevalence of mutations in the GJB2 gene in Portuguese nonsyndromic sensorineural hearing loss (NSSHL) patients. Design: Sequencing of the coding region, basal promoter, exon 1 and donor splice site of the GJB2 gene; screening for the presence of the two common GJB6 deletions. Study sample: A cohort of 264 Portuguese NSSHL patients. Results: At least one out of 21 different GJB2 variants was identified in 80 (30.2%) of the 264 patients analysed. Two mutant alleles were found in 53 (20%) of these probands, of which 83% (44/53) harboured at least one c.35delG allele. Twenty-seven (10.2%) of the probands harboured only one mutant allele. Subsequent analysis revealed that the GJB6 deletion del(GJB6-D13S1854) was present in at least 7.4% (2/27) of the patients carrying only one mutant GJB2 allele. Overall, one in five (55/264) of the patients were diagnosed as having DFNB1-related NSSHL, of which the vast majority (53/55) harboured only GJB2 mutations. Conclusions: This study provides clear demonstration that mutations in the GJB2 gene are an important cause of NSSHL in Portugal, thus representing a valuable indicator as regards therapeutical and rehabilitation options, as well as genetic counseling of these patients and their families.