Browsing by Author "Marcelino, Paulo"
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- Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial CellsPublication . Nunes, Raquel J.; Oliveira, Paula de; Lages, Ana; Becker, Jörg D.; Marcelino, Paulo; Barroso, Eduardo; Perdigoto, Rui; Kelly, Jeffery W.; Quintas, Alexandre; Santos, Susana C. R."Background: The biological effects of transthyretin proteins on vasculature remain unknown. Results: V30M transthyretin tetramer modulates endothelial global gene expression, down-regulating pro-angiogenic genes, inducing apoptosis and inhibiting migration. Conclusion: Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells. Significance: This work has critical implications in the prevention of early hepatic artery thrombosis in familial amyloidotic polyneuropathy patients after liver transplantation."