Percorrer por autor "Hassan, Haidar"
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- Botulinum toxin effects on biochemical biomarkers related to inflammation-associated head and neck chronic conditions : a systematic review of clinical researchPublication . Pereira, Inês Novo; Durão, Sara; Hassan, Haidar; Braga, Ana Cristina; Almeida, André Mariz de; Manso, Ana Cristina; Faria- Almeida, Ricardo; Canales, Giancarlo De la TorreBotulinum toxin type A (BoNT) has emerged as a potential alternative to conventional therapies to many debilitating chronic diseases characterised by inflammatory states. However, the biological rationale remains ambiguous. Our review aimed to systematically assessed which biochemical biomarkers have been reported in clinical research to evaluate BoNT analgesic and mood-lifting effects in head and neck chronic conditions related to inflammation. We searched databases and registries between inception and September 29, 2023. Of the nine included studies, there were concerns about risk of bias for six studies. The leading biomarker with five studies was the calcitonin gene-related peptide (CGRP), followed by serotonin with two studies. Oxidative stress biomarkers were only reported in one study. Several important players in inflammatory processes and different immune cell classes have been evaluated in four studies. There was only one trial measuring changes in beta Tubulin and SNAP-25, and another study evaluating cutaneous neuropeptide substance-P. After BoNT, a significant effect was reported in six studies, including decrease in plasma levels of CGRP in chronic migraine and trigeminal neuralgia; serotonin decrease when collected from human tears in refractory intractable dry eye disease and increase in peripheral blood platelets in painful cervical dystonia associated to depression and anxiety; decrease in plasma concentration of markers of oxidative damage to proteins and increase in biomarkers for antioxidant power; decrease in expression of gene sets involved in inflammatory pathways and immune cells classes in the periosteum and metalloproteinase-9 molecule in the tears. BoNT seems to affect some biomarkers present in chronic inflammatory conditions. However, the certainty evidence found was very low to moderate. This study is registered on PROSPERO (CRD42023432131).
- Botulinum toxin effects on biochemical biomarkers related to inflammation-associated head and neck chronic conditions : a systematic review of preclinical researchPublication . Pereira, Inês Novo; Canales, Giancarlo De La Torre; Durão, Sara; Shado, Rawand; Braga, Ana Cristina; Almeida, André Mariz de; Hassan, Haidar; Manso, Ana Cristina; Faria-Almeida, RicardoCurrent research reported that the number of clinical studies found for botulinum toxin (BoNT) key effects on biochemical biomarkers in head and neck chronic conditions linked to inflammation was very low. There are no systematic reviews of animal studies on this topic, and hence our review aimed to evaluate the quality of the preclinical evidence. We searched PubMed, Scopus, and Web of Science databases, and registries up to 29 January 2024. There were 22 eligible records, and data were available for 11 randomised controlled trials. There were concerns about the risk of bias and great variations of data obtained regarding chronic conditions, which included mostly trigeminal neuralgia. The leading biomarkers were proinflammatory cytokines (IL-1β, TNF-α) and synaptosomal-associated protein-25 (SNAP25), followed by neuron activation marker c-Fos and calcitonin gene-related peptide (CGRP). Overall, data found that BoNT significantly altered the under/over-expression of biomarkers evoked by the investigated disease models and had no effect when the levels of these biomarkers were not changed by the induced chronic conditions in animals. However, there were some mixed results and exceptions, and the certainty evidence found was very low to low. Although the sample sizes detected significant effect size (p < 0.05), most studies are based on male inferior animals, which may limit the recommendations for clinical trials. This study is registered on PROSPERO (CRD42023432411).
- Occlusal vs non-occlusal modality of the loading protocol for oral implants in partially edentulous patients : a systematic review and meta-analysisPublication . Kourkoutis, Panagiotis; Shado, Rawand; Pereira, Ines Novo; Madruga, David; Hassan, HaidarBackground: Occlusal loading refers to a modality in which an implant-supported prosthesis is subjected to functional loading, maintaining contact with the opposing dentition from the onset of prosthetic placement. In contrast, non-occlusal loading represents a non-functional approach, wherein a provisional implant prosthesis is initially placed in infra-occlusion or fully relieved of contact with the opposing dentition, which is subsequently (at a later stage) followed by functional (occlusal) loading with the definitive prosthesis. Aim: To compare clinical outcomes in partially edentulous cases following an occlusal modality of loading versus non-occlusal modality of loading. Method: A search on Pubmed, Scopus and Embase databases was conducted to identify randomised controlled trials (RCTs) comparing occlusal versus non-occlusal modalities of implant loading in partially edentulous patients receiving implants with single crowns or fixed bridges, between January 1 (2004) to June 12 (2024), examining implant survival, complications and marginal bone loss (MBL) of implants. The inclusion criteria involved RCTs of evidence level II (Oxford Centre for Evidence-Based Medicine Levels of Evidence). For assessing bias in the included studies, the Cochrane Risk of Bias tool was used. Results: This review identified seven RCTs investigating 273 implants over 1–3 years follow-up periods. seven studies reported 1-year MBL data and three reported 3-year data. Publication bias was noted at the 1-year follow-up (p < 0.01) but not at 3 years (p > 0.05). Differences in MBL were not statistically significant at both 1 year (Hedges’ d = 0.01, p = 0.920, 95% CI: [−0.21, 0.24]) and 3 years (Hedges’ d = 0.01, p = 0.952, 95% CI: [−0.28, 0.30]). Differences in complication occurrences were not statistically significant (RR = 0.882, p = 0.759, 95% CI: [0.397, 1.964]). The nature of data on implant survival rates prevented a meaningful meta-analysis. Conclusion: For short-term periods of 1–3 years, no significant evidence supports clinical superiority in terms of complication rates and MBL between non-occlusal and occlusal modalities of implant loading. Future studies should explore functional and aesthetic aspects, as well as patient reported outcomes to determine any short-term differences or consider long-term follow-up with large sample sizes to detect significant clinical differences.
- Patient reported pain following tooth extraction with different autologous platelet concentrates : systematic reviewPublication . Hassan, Haidar; Shado, Rawand; Pereira, Ines Novo; Madruga, DavidBackground: Autologous platelet concentrates (APCs) have played a significant role in regenerative dentistry, with clinical evidence suggesting its benefits over controls. Particularly, APCs could reduce postoperative pain following tooth extractions. Aim: To compare patient reported pain after tooth extractions using different autologous platelet concentrates (APCs) such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF). Method: A search on Pubmed, Scopus, Embase and Google Scholar databases was conducted to identify human studies using APC(s) in extraction sockets between January 2014 and June 2024. This review followed the PRISMA guidelines. The inclusion criteria involved comparative human studies ranging from evidence levels II to III (Oxford Centre for Evidence-Based Medicine Levels of Evidence). For assessing bias in the included studies, the Cochrane Risk of Bias tools were used. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to determine the quality of evidence available. Results: This review identified 8 studies; with 338 extraction sites in total and 1–15 days pain follow up. Four studies showed no statistically significant difference in postoperative pain reduction between PRP and PRF. One study observed no statistically significant difference between leukocyte-rich PRF (L-PRF) and titanium-prepared PRF (T-PRF). One study indicated that advanced platelet-rich fibrin (A-PRF) is superior to PRF in reducing postoperative pain on day 2 postoperatively. In addition, two studies reported that A-PRF is more effective than L-PRF on day 2. Moderate-to-high risk of bias was identified within 75% of the selected papers. GRADE score for evidence quality assessment was ‘Low’. Conclusion: A-PRF was favoured to reduce postoperative pain on day 2 among the investigated APCs, although the GRADE criteria rate the evidence as “Low”. Future trials should directly compare A-PRF with PRF and L-PRF using high-quality randomized controlled designs.