Browsing by Author "Fernandes, J"
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- Angioplastia CarotídeaPublication . Ribeiro, M; Xavier, J; Ferreira, C; Fernandes, J; Magalhães, Z; Rocha, J
- Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young ObesePublication . Belo, L; Nascimento, H; Kohlova, M; Bronze-da-Rocha, E; Fernandes, J; Costa, E; Catarino, C; Aires, L; Mansilha, HF; Rocha-Pereira, P; Quintanilha, A; Rêgo, C; Santos-Silva, AOBJECTIVES: Bilirubin has potential antioxidant and anti-inflammatory properties. The UGT1A1*28 polymorphism (TA repeats in the promoter region) is a major determinant of bilirubin levels and recent evidence suggests that raised adiposity may also be a contributing factor. We aimed to study the interaction between UGT1A1 polymorphism, hematological and anthropometric variables with total bilirubin levels in young individuals. METHODS: 350 obese (mean age of 11.6 years; 52% females) and 79 controls (mean age of 10.5 years; 59% females) were included. Total bilirubin and C-reactive protein (CRP) plasma levels, hemogram, anthropometric data and UGT1A1 polymorphism were determined. In a subgroup of 74 obese and 40 controls body composition was analyzed by dual-energy X-ray absorptiometry. RESULTS: The UGT1A1 genotype frequencies were 49.9%, 42.7% and 7.5% for 6/6, 6/7 and 7/7 genotypes, respectively. Patients with 7/7 genotype presented the highest total bilirubin levels, followed by 6/7 and 6/6 genotypes. Compared to controls, obese patients presented higher erythrocyte count, hematocrit, hemoglobin and CRP levels, but no differences in bilirubin or in UGT1A1 genotype distribution. Body fat percentage was inversely correlated with bilirubin in obese patients but not in controls. This inverse association was observed either in 6/7 or 6/6 genotype obese patients. UGT1A1 polymorphism and body fat percentage were the main factors affecting bilirubin levels within obese patients (linear regression analysis). CONCLUSION: In obese children and adolescents, body fat composition and UGT1A1 polymorphism are independent determinants of total bilirubin levels. Obese individuals with 6/6 UGT1A1 genotype and higher body fat mass may benefit from a closer clinical follow-up.
- Cerebral venous thrombosis in a patient with localised sclerodermaPublication . Rocha, J; Pinho, J; Fernandes, J; Ferreira, C; Macedo, C; Fontes, JR; Perdigão, S
- Envolvimento meníngeo em caso de esclerodermia localizadaPublication . Carvalho, R; Fernandes, J; Ribeiro, M; Morais, N; Moreira da Costa, JA; Magalhães, Z; Rocha, J
- Esophageal Anastomotic Stricturotomy: Electroincision Therapy with a Needle KnifePublication . Fernandes, J; Libânio, D; Giestas, S; Ramada, J; Martinez-Ares, D; Canena, J; Lopes, L
- Exploring Cannabidiol (CBD) and Cannabigerol (CBG) Safety Profile and Skincare PotentialPublication . Luz-Veiga, M; Mendes, A; Tavares-Valente, D; Amorim, M; Conde, A; Pintado, ME; Moreira, HR; Azevedo-Silva, J; Fernandes, JCannabinoids have long been known for their bioactive properties, with their topical application as anti-inflammatory compounds being at the forefront of research for the past decade. Concurrently, the cosmetic market is a fast-growing industry in constant need of new biomolecules. In this work, we studied the safety profile for topical applications of two cannabinoids: cannabidiol (CBD) and cannabigerol (CBG) and assessed their potential as skin care ingredients. The CBG used in this work resulted from bio-fermentation, and to the best of our knowledge, there are no extensive reports on its safety and usage as a cosmetic ingredient. Our results show that CBD and CBG do not exhibit cytotoxicity, mutagenicity, or skin sensitization. Moreover, we verified an absence of primary irritability, accumulated irritability, phototoxicity and photosensitization, supporting the claims of dermatologically tested, hypoallergenic and non-irritating. While these cannabinoids did not show significant anti-aging effects by altering the extracellular matrix components (both in vitro and ex vivo), they demonstrated promise as protective agents against inflammation caused by air pollution. Specifically, they reduced the levels of pro-inflammatory cytokines, making them valuable in combating environmental skin damage. Overall, our results validate the safety of topical use of cannabinoids, while paving the way for further research in the beauty and personal care market as soothing agents.
- Factors Influencing Performance of Cholangioscopy-Guided Lithotripsy Including Available Different Technologies: A Prospective Multicenter Study with 94 PatientsPublication . Alexandrino, G; Lopes, L; Fernandes, J; Moreira, M; Araújo, T; Campos, S; Loureiro, R; Figueiredo, L; Lourenço, LC; Horta, D; Bana e Costa, T; Costa, P; Canena, JBackground: Peroral cholangioscopy (POC)-guided lithotripsy is an effective treatment for difficult biliary stones. A clear definition of factors associated with the efficacy of POC-guided lithotripsy in one session and the performance of electrohydraulic lithotripsy (EHL) and laser lithotripsy (LL) have not clearly emerged. Methods: This was a non-randomized prospective multicenter study of all consecutive patients who underwent POC lithotripsy (using EHL and/or LL) for difficult biliary stones. The primary endpoint of the study was the number of sessions needed to achieve complete ductal clearance and the factors associated with this outcome. Secondary endpoints included the evaluated efficacies of LL and EHL. Results: Ninety-four patients underwent 113 procedures of EHL or LL. Complete ductal clearance was obtained in 93/94 patients (98.94%). In total, 80/94 patients (85.11%) achieved stone clearance in a single session. In the multivariate analysis, stone size was independently associated with the need for multiple sessions to achieve complete ductal clearance (odds ratio = 1.146, 95% confidence interval: 1.055-1.244; p = 0.001). Using ROC curves and the Youden index, 22 mm was found to be the optimal cutoff for stone size (95% confidence interval: 15.71-28.28; p < 0.001). The majority of the patients (62.8%) underwent LL in the first session. Six patients failed the first session with EHL after using two probes and therefore were crossed over to LL, obtaining ductal clearance in a single additional session with a single LL fiber. EHL was significantly associated with a larger number of probes (2.0 vs. 1.02) to achieve ductal clearance (p < 0.01). The mean procedural time was significantly longer for EHL than for LL [72.1 (SD 16.3 min) versus 51.1 (SD 10.5 min)] (p < 0.01). Conclusions: POC is highly effective for difficult biliary stones. Most patients achieved complete ductal clearance in one session, which was significantly more likely for stones < 22 mm. EHL was significantly associated with the need for more probes and a longer procedural time to achieve ductal clearance.
- Hematoma subdural raquidianoPublication . Ribeiro, M; Cerqueira, J; Fernandes, J; Alegria, C; Rocha, JSpinal subdural haematoma is a rare pathology and may cause severe neurological deficit. In this paper a case of acute spinal subdural haematoma of multifactorial etiology--traumatic versus iatrogenic--is presented, in which the clinical evaluation, Computerized Tomography and Magnetic Resonance were of utmost importance as far as the early diagnosis is concerned, allowing therefore decompressive surgery to avoid neurological deficit development.
- Reverse crossed cerebellar diaschisisPublication . Ribeiro, M; Beleza, P; Fernandes, J; Almeida, F; Rocha, JCerebral Magnetic Resonance imaging in acute postictal period is performed to exclude structural processes that can be responsible for the epileptic activity. Sometimes, the findings are the result of the epileptic activity, and not the cause reflecting the pathophysiologic changes during epileptic activity. In this paper we describe a patient with status epilepticus who has developed hemicerebellar involvement contralateral to a frontal epileptogenic focus. This phenomenon of Reverse Crossed Cerebellar Diaschisis is rare and has been describe only in Single Photon Emission Computed Tomography (SPECT).
- Transient ischemic attacks in a child with post-varicella arteriopathy and MTHFR homozigotic mutation C677TPublication . Beleza, P; Fernandes, J; Afonso, A; Silva, H; Jordão, MJ