Percorrer por autor "Costa, Rui"
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- Categorização CIF de instrumentos de medida e intervenções utilizados na Fisioterapia em sujeitos com AVCPublication . Almeida, Patrícia; Pereira, Carla; Santos, Hugo; Martins, Anabela; Vital, Emanuel; Noronha, Teresinha; Costa, Rui; Jacobsohn, Lia; Castro-Caldas, AlexandreDe forma a melhor programar e obter resultados em investigação e planos de intervenção clínicos, no contexto da Fisioterapia, é necessária uma relação clara entre tipologias de intervenção, problemas a resolver, resultados esperados e instrumentos de avaliação aplicados. A Classificação Internacional de Funcionalidade (CIF) e os Core Sets já desenvolvidos são uma estrutura que facilita esta relação e organização. A aplicação das regras de correspondência entre as categorias da CIF, as intervenções e os instrumentos de medida poderão ser a forma facilitadora para este processo. O objetivo deste estudo é propor a categorização dos instrumentos de medida e intervenções da Fisioterapia, no contexto da reabilitação de sujeitos com Acidente Vascular Cerebral (AVC). Quarenta e três intervenções e 65 instrumentos de medida foram categorizados em 43 categorias e códigos relacionados com o movimento, pertencentes ao Core Set para AVC, de acordo com as regras de correspondência. Foi feita uma proposta inicial de categorização e a sua validação foi feita por sete Fisioterapeutas peritos no uso da CIF e em neurologia, através do método de Delphi modificado. Os resultados demonstram que os instrumentos de medida foram categorizados num total de 243 categorias de 2.º nível da CIF: “funções” – 86; “estruturas” – 11; “atividade” – 125, e “participação” – 20. As intervenções foram categorizadas num total de 223 categorias de 2.º nível da CIF: “funções” – 97; “estruturas” – 18; “atividade” – 106, e “participação” – 2. Conclui-se que é consensual, para este painel de peritos, que são os construtos das “funções do corpo” e “atividades” que melhor expressam a caracterização dos instrumentos de medida e as intervenções realizadas no contexto da Fisioterapia a sujeitos que sofreram AVC. Esta categorização deve ser validada ao nível internacional.
- Characterization of Antidepressant Consumption in a Portuguese Inland Population.Publication . Soares, Sofia; Rosado, Tiago; Santos, Vítor Hugo; Rei, Cristina; Amantegui, Patricia; Pissarra da Costa, António; Chaves, Telma; Valente, Rita; Duarte, Fábio; Pacheco, Susana; Martins, Marco; Dias, Kátia; Costa, Patricia; Costa, Rui; Castro, Sílvia; Sousa, Diana; Figueiredo, Diana; Soares, Isabel; Mouta, Salomé; Jesus, Bianca; Pires, Ana; Ribeiro, Cândida; Lobo, Sónia; Correia, Leonor; Malés, Sofia; Vale, Fátima; Moita, Carina; Moura, Carolina; Sousa, Joana; Afonso, Luís Rafael; Costa, Rita Santinho; Barroso, Mário; Gallardo, EugeniaMental disorders are a growing global concern, with depression being among the most prevalent. Portugal ranks second in antidepressant consumption within the OECD, following a threefold increase between 2000 and 2020. In inland regions such as Beira Interior, reduced healthcare services and distance from major hospitals further complicate access to care. This study analysed 142 patients from Beira Interior undergoing antidepressant therapy to characterise their demographic and clinical profile and to assess associations with adverse effects. A cross-sectional survey collected demographic data, clinical diagnoses, prescribed antidepressants, concomitant medications, and reported adverse effects. Both descriptive and inferential statistical analyses were performed. Most participants were female (81.0%), with a mean age of 57.8 years. Major depression was the most common diagnosis (76.1%). Selective serotonin reuptake inhibitors (47.4%) and trazodone (27.8%) were the most prescribed agents. Treatment had lasted one to five years in 59.9% of cases. Concomitant use of benzodiazepines (76.8%) and antipsychotics (48.6%) was frequent. Reported adverse effects included anticholinergic symptoms (38.7%) and confusion/agitation (26.8%). Women were more likely to use serotonin modulators, while patients >64 years had higher odds of using tetracyclic/unicyclic antidepressants, serotonin modulators, and multiple antidepressants. These classes were significantly associated with increased adverse effects. The findings reveal important risks related to polypragmasia and adverse reactions, underscoring the need for individualised prescribing, rigorous monitoring, and strict adherence to guidelines. Larger, stratified, and longitudinal studies are needed to clarify causality and optimise treatment outcomes.
- Chromatographic determination of antidepressants in plasma and saliva: Towards non-invasive therapeutic monitoringPublication . Soares, Sofia; Rosendo, Luana; Fonseca, Suzana; Gonçalves, Nuno; Franco, João; da Costa, António Pissarra; Rosado, Tiago; Barroso, Mário; Santos, Vítor Hugo; Rei, Cristina; Amantegui, Patricia; Chaves, Telma; Valente, Rita; Duarte, Fábio; Pacheco, Susana; Martins, Marco; Dias, Kátia; Costa, Patricia; Costa, Rui; Castro, Sílvia; Sousa, Diana; Figueiredo, Diana; Soares, Isabel; Mouta, Salomé; Jesus, Bianca; Pires, Ana; Ribeiro, Cândida; Lobo, Sónia; Correia, Leonor; Malés, Sofia; Vale, Fátima; Moita, Carina; Moura, Carolina; Sousa, Joana; Afonso, Luís Rafael; Costa, Rita Santinho; Gallardo, EugeniaDrug monitoring of antidepressants in plasma and oral fluid represents a valuable tool in clinical practice, enabling the optimisation of treatment efficacy and the reduction of adverse effects. Given the significant interindividual variability in antidepressant response-driven by factors such as metabolism, drug-drug interactions, and adherence to therapy-drug monitoring facilitates dose adjustment based on measured drug concentrations, ensuring levels remain within the therapeutic window. This study aimed at developing and validating a robust, rapid, and sensitive method for the simultaneous quantification of 21 selected antidepressants and their metabolites in only 100 μL of plasma and oral fluid. Sample preparation was performed using a simple protein precipitation protocol, followed by analysis via liquid chromatography-tandem mass spectrometry (LC-MS/MS). The method was validated in accordance with internationally accepted bioanalytical guidelines, demonstrating linearity over the concentration range of 0.98-1000 ng/mL. Limits of quantification were established at 0.98 ng/mL for all analytes across both matrices. The extraction procedure yielded high recovery rates, and the method showed excellent selectivity, sensitivity, precision, and accuracy, confirming its suitability for routine toxicological applications. The validated method was successfully applied to 142 paired authentic plasma and oral fluid specimens from patients undergoing antidepressant therapy. Antidepressant concentrations were determined in both matrices, and treatment adherence was considered high, being confirmed in 88.7 % of patients. Correlation analysis between plasma and oral fluid concentrations produced promising results for several of the compounds under investigation, reinforcing the potential utility of oral fluid as a non-invasive alternative matrix in drug monitoring.
- Clinical education reflective ecological model for health science majorsPublication . Mendes, Ana; Martins, Paula; Alarcão, Isabel; Melo, Elsa; Pereira, João C.; Rua, Marília; Brandão, Piedade; Costa, Rui; Sancho, LuísThe clinical education is an integral part of the Health Science majors’ curriculum programs of the University of Aveiro’s School of Health (i.e., Nursing, Physical Therapy, Radiology, Radiotherapy and Speech-Language Pathology) and aims to develop clinical competences in order to generate excellent health care professionals. The organization was based on the Ecological Model of Clinical-Reflective Training, which was characterized by inter-institutional interaction and student’s reflection on actions on a professional setting. This study encompassed two moments of clinical internships in the Nursing, Physical Therapy, Radiology and Radiotherapy majors. The Clinical Internship I provided the 123 students with a global view of the health care professional activities. The Clinical Internship II, with 119 students, developed competences of each health professional. Questionnaires with categorical scales from 1 to 5 evaluated the organization and efficiency of the two internships. The results revealed averages over 3 in all items. In conclusion, the Ecological Model of Clinical-Reflective Training was well accepted by students and clinical supervisors. Applications in the health care area were demonstrated.
- Plano de marketing: AutoTestPublication . Costa, Rui; Rodrigues, FilipeA fusão de 5 centros de inspeção automóvel levou à necessidade de criação de uma marca para corresponder da melhor forma aos desafios do mercado. A marca AutoTest foi criada com esse intuito e este documento explora as bases para a sua implementação. De facto, é elaborado um plano de marketing com o objetivo de servir como ferramenta orientadora nessa implementação. Na criação deste plano foi usada a metodologia de action research para a obtenção de dados. Na verdade, este plano de marketing apresenta 13 ações distribuídas por 5 áreas estratégicas de marketing. Através da construção deste plano, foi possível concluir que o mercado das inspeções automóveis é bastante regulado e que para estar na vanguarda desse mercado é necessário encontrar novas formas de criar valor para o cliente como uma comunicação eficaz e um serviço complementado com ações além das inspeções.