Browsing by Author "Costa, L."
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- Portuguese recommendations for the use of biological therapies in patients with axial spondyloarthritis – 2016 updatePublication . Machado, P. M.; Cerqueira, M.; Ávila-Ribeiro, P.; Aguiar, R.; Bernardo, A.; Sepriano, A.; Águeda, A.; Cordeiro, A.; Raposo, A.; Rodrigues, A. M.; Barcelos, A.; Malcata, A.; Lopes, C.; Vaz, C. C.; Nour, D.; Godinho, F.; Alvarenga, F.; Pimentel-Santos, F.; Canhão, H.; Santos, H.; Cunha, I.; Neves, J. S.; Fonseca, J. E.; Gomes, J. L.; Tavares-Costa, J.; Costa, L.; Cunha-Miranda, L.; Maurício, L.; Cruz, M.; Afonso, M. C.; Santos, M. J.; Bernardes, M.; Valente, P.; Figueira, R.; Pimenta, S.; Ramiro, S.; Pedrosa, T.; Costa, T. A.; Vieira-Sousa, E.; Portuguese Society of Rheumatology
- Portuguese Recommendations for the use of biological therapies in patients with rheumatoid arthritis- 2016 updatePublication . Duarte, C.; Sousa-Neves, J.; Águeda, A.; Ribeiro, P.; Daniel, A.; Eugénio, G.; Serra, S.; Araújo, F.; Barcelos, A.; Filipe, B.; Bernardes, M.; Canhão, H.; Cerqueira, M.; Capela, S.; Cordeiro, A.; Costa, F.; Costa, L.; Cruz, M.; Cunha-Miranda, L.; Duarte, C.; Falcão, S.; Faria, D.; Figueira, R.; Freitas, J. P.; Gonçalves, M. J.; Madruga Dias, J.; Melo Gomes, J.; Mourão, A. F.; Neto, A.; Oliveira Ramos, F.; Pimenta, S.; Pinto, P.; Polido-Pereira, J.; Ponte, C.; Ramos, J.; Rodrigues, A.; Santos, H.; Santos, M. J.; Sepriano, A.; Silva, C.; Tavares Costa, J.; Teixeira, F.; Teixeira, V.; Valente, P.; Vieira-Sousa, E.; Barros, R.; Abreu, P.; Fonseca, J. E.
- Portuguese recommendations for the use of methotrexate in rheumatic diseases – 2016 updatePublication . Duarte, A. C.; Santos-Faria, D.; Gonçalves, M. J.; Sepriano, A.; Mourão, A. F.; Duarte, C.; Neves, J. S.; Águeda, A. F.; Ribeiro, P. A.; Daniel, A.; Neto, A.; Cordeiro, A.; Rodrigues, A.; Barcelos, A.; Silva, C.; Ponte, C.; Vieira-Sousa, E.; Teixeira, F.; Oliveira-Ramos, F.; Araújo, F.; Barcelos, F.; Canhão, H.; Santos, H.; Ramos, J.; Polido-Pereira, J.; Tavares-Costa, J.; Melo Gomes, J. A.; Cunha-Miranda, L.; Costa, L.; Cerqueira, M.; Cruz, M.; Santos, M. J.; Bernardes, M.; Oliveira, P.; Abreu, P.; Figueira, R.; Barros, R.; Falcão, S.; Pinto, P.; Pimenta, S.; Capela, S.; Teixeira, V.; Fonseca, J. E.; Portuguese Society of Rheumatology
- The benefit of macrolide therapy in patients with pneumococcal pneumonia is only present in patients with bacteremiaPublication . Gonçalves-Pereira, J.; Costa, L.; Silva, I.; Simões, A.; Froes, F.; Mergulhão, P.; Varela Ramos, P.; Leal, D.; Alves, R.; Custódio, M.; Gomes, A.
- The benefit of macrolide therapy in patients with pneumococcal pneumonia is only present in patients with bacteremiaPublication . Gonçalves-Pereira, J.; Costa, L.; Silva, I.; Simões, A.; Froes, F.; Mergulhão, P.; Varela Ramos, P.; Leal, D.; Alves, R.; Custódio, M.; Gomes, A.
- The cancer registry as an ally in monitoring treatment effectivenessPublication . Costa, F. A.; Ramos, C.; Murteira, R.; Almodovar, T.; Passos-Coelho, J. L.; Carvalho, M. I.; Costa, L.; Brito, M. J.; Ramos, S.; Ferreira, M.; Miranda, A. C.OBJECTIVE: To evaluate if the cancer registry database can be used to monitor treatment effectiveness using nivolumab treatment of non-small cell lung cancer (NSCLC) as an example. METHOD: An observational inception cohort was used, where all registered cases of NSCLC with authorisation to initiate treatment with nivolumab were monitored retrospectively to evaluate disease characteristics and response to prior treatments. Current exposure to nivolumab was prospectively characterised and treatment outcomes classified based on the clinical information registered in the patient medical record. The main outcome measure used to assess treatment effectiveness was overall survival (OS). Secondary outcomes considered were progression free survival (PFS) as a measure of effectiveness and occurrence of Adverse Drug Reaction (ADRs) as a measure of safety. Data were analysed using SPSS, version 24. RESULTS: A total of 115 patients received treatment with nivolumab for NSCLC, between November 1st 2015 and July 31st 2016, and were registered in the database. The majority were non-squamous type (n=107). The median OS was 11.4 months {CI95%: 11.1-11.7}, with a 1-year survival of 44%, in line with clinical trial data. Median PFS was 5.4 months {CI95%: 2.8-7.9}. Treatment was discontinued in 82 cases, most frequently due to disease progression. There were 38 cases of ADRs documented in the patient medical chart, 21 of which led to treatment discontinuation. CONCLUSION: The analysed data suggest that the cancer registry is a powerful tool to monitor treatment effectiveness, although considerable investment is needed to improve the medical culture of recording treatment exposure, particularly documentation of ADRs.