Percorrer por autor "Carvalho, Fátima"
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- A comprehensive ecotoxicological evaluation of a treated olive mill wastewater and obtained sludgePublication . Pinto, José N.; Pereira, Andreia; Silva, Ana Rita. R.; Cardoso, Diogo N.; Mostafaie, Amid; Campos, Fábio; Rehan, Iryna; Moreira, Olga; Lopes, Ivã Guidini; Murta, Daniel; Afonso, Alexandra; Oliveira, Margarida; Silvério, Karina S.; Santos, Maria Teresa; Carvalho, Fátima; Almeida, Adelaide; Loureiro, SusanaOlive mill wastewaters (OMWWs) are an environmental problem in the Mediterranean region, and it is crucial to explore strategies for their treatment and repurposing. The chemical precipitation technique (CPT) has been presented as a cost-effective wastewater treatment solution that might be applied to OMWW. The CPT-resulting precipitant subproducts (sludge) may be reprocessed (e.g., agricultural fertilizer and/or soil amendment), while the treated wastewater may be repurposed or reused (e.g., irrigation, aquaponic, or industrial processes). This study aimed to evaluate the efficacy of CPT in treating wastewater from the olive oil industry from an ecotoxicological perspective. Additionally, to assess the safe use of the obtained sludge in CPT treatment, its effects on soil biota were assessed. For this, a set of ecotoxicological assays using freshwater (Raphidocelis subcapitata, Daphnia magna and Danio rerio), terrestrial invertebrates (Folsomia candida and Enchytraeus crypticus), and plants (Brassica oleracea and Lolium perenne) were used as model organisms. Results demonstrated that CPT reduced OMWW toxicity to freshwater organisms, offering a favorable outlook on CPT’s potential as a wastewater treatment method. Increasing application rates of sludge in soil reduced the shoot biomass and the hydric content of both plants compared to the control. Survival of F. candida and E. crypticus was not affected by sludge in soil at any tested application rate, yet sludge application negatively affected the reproduction of both species, even at relevant sludge application rates (2%) of sludge in soils. Overall, the applicability of this sludge obtained by the CPT treatment in soils should be carefully evaluated due to the observed adverse effects on soil biota. Although the results of CPT were promising in reducing the toxicity of OMWW for these aquatic species, some adjustments/improvements should be performed to improve this technique and use all the obtained resources (treated water and sludge) in a fully circular perspective.
- Evaluating mechanical properties of Paroxetine loaded filaments to enable printability by fused deposition modellingPublication . Figueiredo, Sara; Fernandes, Ana I.; Carvalho, Fátima; Pinto, João F.
- Implementação e qualificação de uma área de embalagem de formas farmacêuticas sólidasPublication . Correia, João; Toscano, Cristina; Carvalho, Fátima
- Impressão tridimensional — 3D-PRINTING (3DP) — Uma estratégia inovadora para a produção de medicamentosPublication . Figueiredo, Sara; Brízio, Ana; Carvalho, Fátima; Fernandes, Ana I.; Pinto, João F.
- Mechanical properties as printability predictors of Paroxetine-loaded filaments by fused deposition modelingPublication . Figueiredo, Sara; Fernandes, Ana I.; Carvalho, Fátima; Rato, Paula; Pinto, João F.
- Production of individualized medicines by additive manufacture (3D-printing)Publication . Figueiredo, Sara; Carvalho, Fátima; Fernandes, A.I.; Pinto, João F.
- Production of individualized medicines by additive manufacture (3D-printing)Publication . Figueiredo, Sara; Carvalho, Fátima; Fernandes, A.I.; Pinto, João F.
- Treatment of feline lung–digit syndrome with toceranib phosphate : prolonged survival and novel metastatic findingsPublication . Cabral, Inês; Matos, Gustavo; Silva, Gabriela Fernandes; Carvalho, Fátima; Amorim, IrinaFeline pulmonary carcinomas are rare and often carry a poor prognosis, particularly when associated with feline lung–digit syndrome. We report a cat with primary pulmonary carcinoma and extensive metastases—including digits, pleura, mandible, scapula, spleen, skeletal muscle, and distant lymph nodes—supporting the broader “MODAL syndrome” concept. Palliative therapy with toceranib phosphate and meloxicam achieved prolonged survival and excellent quality of life, with no adverse effects despite dose escalation. Rapid progression after discontinuation suggests a role for toceranib in delaying tumour growth. Immunohistochemistry revealed c-kit expression in one metastatic lesion but not in the primary tumour or most metastases, highlighting intratumoral heterogeneity and the complexity of targeted therapy. The observed benefit likely reflects toceranib’s multi-target activity (VEGFR2, PDGFR), impacting angiogenesis and tumour progression. This case represents the first report of toceranib phosphate use in feline pulmonary carcinoma and underscores its potential as a palliative option.