Percorrer por autor "Ascenso, Carla"
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- Bridging generations through integrative learning, research, and community care : The ESPIEM ProjectPublication . Auxtero, Maria Deolinda; Costa, Isabel Margarida; Brito, José; Figueiredo, Alexandra; Ascenso, Carla; Miranda, Margarida; Caneiras, Cátia; Fernandes, Ana IsabelCommunication abstract presented at the EAFP Annual Conference 2025 – “Pharmaceutical Education & Research: SWOT Analysis”. Faculty of Pharmacy, University of Coimbra, 13th-15th of May 2025
- Bridging generations through integrative learning, research, and community care : the ESPIEM projectPublication . Auxtero, Maria Deolinda; Costa, Isabel Margarida; Brito, José; Figueiredo, Alexandra; Ascenso, Carla; Miranda, Margarida; Caneiras, Cátia; Fernandes, Ana IsabelCommunication presented at the EAFP - Annual Conference 2025 "Pharmaceutical Education and Research: SWOT Analysis." Coimbra, Portugal, 13-15 May 2025
- Effects of probiotic short-term regiment on oral health parameters in children : a pilot randomized controlled trialPublication . Starck, Edouard; Machado, Vanessa; Botelho, João; Proença, Luís; Barroso, Helena; Ascenso, Carla; Rozan, CecíliaBackground/Objectives: Streptococcus mutans (S. mutans) is a primary cariogenic bacterium contributing to biofilm acidogenicity and enamel demineralization. Conventional caries prevention relies mainly on mechanical plaque control and dietary modification, but probiotics have emerged as potential adjuncts for oral microbiota modulation. This pilot randomized controlled trial aimed to evaluate the short-term effects of a multi-strain probiotic containing Lactobacillus and Bifidobacterium on clinical and microbiological parameters associated with dental caries in children. Methods: A double-blind, randomized, placebo-controlled clinical trial was conducted in 40 children aged 6–14 years from a community setting. Participants were randomly allocated (1:1) to receive either probiotic or placebo lozenges for 30 days. Clinical assessments included the Gingival Index (GI), Plaque Index (PI), International Caries Detection and Assessment System (ICDAS), salivary pH, buffering capacity, and salivary S. mutans concentration. The study was preregistered (10.17605/OSF.IO/GKVUW) and ethically approved. Results: The intervention was well tolerated, with no adverse events reported and high participant acceptability. Despite there being no statistically significant differences in any clinical or microbiological parameter (p > 0.05), we found trends toward higher salivary pH, improved buffering capacity, and reduced S. mutans counts in the probiotic group. Conclusions: Short-term probiotic supplementation was safe and well accepted among children but did not produce statistically significant improvements in oral health parameters over 30 days. These findings highlight the feasibility of probiotic use in pediatric populations and support the need for larger, longer-term trials to clarify their potential role as adjuncts in caries prevention.
- pH analysis of still and carbonated bottled water : potential influence on dental erosionPublication . Morgado, Mariana; Ascenso, Carla; Carmo, Joana; Mendes, José João; Manso, Ana CristinaObjective: To assess pH values to characterize bottled water in Portugal, being able to provide information for both patients and clinicians about its erosive potential, as a tool to prevent the ingrowing prevalence of dental erosion and its progression, especially in patients who are at greater risk, such as those with dry mouth syndrome, making the dissemination of this knowledge a fundamental tool for clinical decision. Materials and Methods: One hundred and five common brands of bottled water (n = 105), commercialized in Portugal, were analyzed. Of these, 73 were smooth water (Group A) and 32 carbonated water (Group B). All pH values were assessed by potentiometric measurement with a calibrated electrode. For each brand, five independent measurements were recorded at 25°C for further calculation of the mean pH value and standard deviation. Results: Focusing on the mean pH values from Group A, one had a pH mean value lower than 5.2, four between 5.2 and 5.5, thirty-seven between 5.5 and 6.8, and thirty-one higher than 6.8. In Group B, ten had a mean pH value lower than 5.2, ten between 5.2 and 5.5, twelve between 5.5 and 6.8, and none above 6.8. Conclusions: Bottled water, commercialized in Portugal, has different mean pH values, some below the critical threshold of enamel and/or dentin, suggesting that they may have a greater risk of consumption than others, only with respect to the pH parameter of erosive potential. Further investigation concerning this area is needed for wider conclusions.
- What is the best etching timing in a resin infiltrant used on enamel surface after remineralization with CPP-ACP?Publication . Carmo, Joana; Ascenso, Carla; Jorne, Ana; Peixoto, André; Nogueira, Isabel; Manso, Ana Garcia