Browsing by Author "Alves, Daniela"
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- Differential patterns of postmigration HIV-1 infection acquisition among Portuguese immigrants of different geographical originsPublication . Pimentel, Victor Figueiredo; Pingarilho, Marta; Sole, Giordano; Alves, Daniela; Miranda, Mafalda; Diogo, Isabel; Fernandes, Sandra; Pineda-Pena, Andrea; Martins, M. Rosário O; Camacho, Ricardo; Gomes, Perpétua; Abecasis, Ana B.Objective: To investigate the dynamics of phylogenetic transmission clusters involving immigrants of Portuguese Speaking Countries living in Portugal. Design/methods: We included genomic sequences, sociodemographic and clinical data from 772 HIV migrants followed in Portugal between 2001 and 2017. To reconstruct HIV-1 transmission clusters, we applied phylogenetic inference from 16 454 patients: 772 migrants, 2973 Portuguese and 12 709 global controls linked to demographic and clinical data. Transmission clusters were defined using: clusters with SH greater than 90% (phylogenetic support), genetic distance less than 3.5% and clusters that included greater than 66% of patients from one specific geographic origin compared with the total of sequences within the cluster. Logistic regression was performed to assess factors associated with clustering. Results: Three hundred and six (39.6%) of migrants were included in transmission clusters. This proportion differed substantially by region of origin [Brazil 54% vs. Portuguese Speaking African Countries (PALOPs) 36%, P < 0.0001] and HIV-1 infecting subtype (B 52%, 43% subtype G and 32% CRF02_AG, P < 0.001). Belonging to a transmission cluster was independently associated with treatment-naive patients, CD4+ greater than 500, with recent calendar years of sampling, origin from PALOPs and with seroconversion. Among Brazilian migrants – mainly infected with subtype B – 40.6% were infected by Portuguese. Among migrants from PALOPs – mainly infected with subtypes G and CFR02_AG – the transmission occurred predominantly within the migrants’ community (53 and 80%, respectively). Conclusion: The acquisition of infection among immigrants living in Portugal differs according to the country of origin. These results can contribute to monitor the HIV epidemic and prevent new HIV infections among migrants.
- IDN Jovem : 8º Seminário "IDN Jovem"Publication . Ilin, Aleksandr; Pereira, Marta Lima; Matias, Leandro; Areias, Helena; Gonçalves, Mariana; Cardoso, Miguel; Silva, João; Suamo, Vasco; Falcone, Pedro; Rodrigues, Beatriz; Sousa, Rodrigo; Guimarães, Petra; Ribeiro, Ana; Pacheco, Miguel; Alves, Carolina; Gama, Lara; Oliveira, Raquel; Simões, Joana; Gato, Débora; Pintado, Mafalda; Moreira, Wendy; Alves, Daniela; Rosa, Salomé; Barqueiro, Beatriz
- Lacunas da Legislação sobre Segurança Contra Incêndio em Edifícios (SCIE)Publication . Alves, DanielaO presente estudo tem como objetivo principal analisar as lacunas existentes no quadro normativo da segurança contra incêndio em edifícios em Portugal. A metodologia de trabalho que foi adotada foi pesquisa bibliográfica e estudo de casos. Os resultados evidenciam lacunas ao nível da Retificação da Densidade de Carga de Incêndio Modificadas da Utilização - Tipo XI – Regime Jurídico – Segurança Contra Incêndio em Edifícios, bem como insuficientes disposições relativas a recintos de eventos, insuficientes disposições relativas a estacionamentos descobertos e cobertos nas diversas utilizações-tipo e a inexistência de simulacros para as utilizações tipo IV, V e VII da 1.ª categoria de risco com locais de risco D ou E e da 2.ª categoria de risco sem locais de risco D ou E. Conclui-se que é necessária uma revisão normativa do quadro legal que abriga a segurança contra incêndio em edifícios, nomeadamente em relação às utilizações-tipo VI.
- Molecular epidemiology of HIV-1 infected migrants followed up in Portugal: trends between 2001–2017Publication . Pimentel, Victor; Pingarilho, Marta; Alves, Daniela; Diogo, Isabel; Fernandes, Sandra; Miranda, Mafalda; Pineda-Peña, Andrea-Clemencia; Libin, Pieter; Martins, M. Rosário O.; Vandamme, Anne-Mieke; Camacho, Ricardo; Gomes, Perpétua; Abecasis, AnaMigration is associated with HIV-1 vulnerability. Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorithms were used for subtyping. Transmitted drug resistance (TDR) and Acquired drug resistance (ADR) were defined as the presence of surveillance drug resistance mutations (SDRMs) and as mutations of the IAS-USA 2015 algorithm, respectively. Statistical analyses were performed. Results: HIV-1 subtypes infecting migrants were consistent with the ones prevailing in their countries of origin. Over time, overall TDR significantly increased and specifically for Non-nucleoside reverse transcriptase inhibitor (NNRTIs) and Nucleoside reverse transcriptase inhibitor (NRTIs). TDR was higher in patients from Mozambique. Country of origin Mozambique and subtype B were independently associated with TDR. Overall, ADR significantly decreased over time and specifically for NRTIs and Protease Inhibitors (PIs). Age, subtype B, and viral load were independently associated with ADR. Conclusions: HIV-1 molecular epidemiology in migrants suggests high levels of connectivity with their country of origin. The increasing levels of TDR in migrants could indicate an increase also in their countries of origin, where more efficient surveillance should occur.