Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.26/6781
Registo completo
Campo DCValorIdioma
dc.contributor.authorSantos, C.-
dc.contributor.authorCarmezim, M. J.-
dc.contributor.authorValido, A. J.-
dc.contributor.authorColaço, B.-
dc.contributor.authorFernandes, M. H.-
dc.contributor.authorGomes, P.-
dc.descriptionCom o apoio RAADRI.por
dc.descriptionAbstract de apresentação de poster em conferência.por
dc.description.abstractOsteoporosis is a clinical condition characterized by an increased risk of bone fracture. Structural fragility seems to result from a reduction in bone mass due to a decreased mineral content and impaired/altered protein synthesis. Despite the established knowledge on osteoporosis, little is known on how these compositional changes may affect the bone microarchitecture throughout different bones, and how these correlate with the attained increase of the fracture risk. This work aims to examine the relation between bone material properties and skeletal fragility in the femur, tibia, maxilla, mandible and calvarial structure of an animal model representative of the human osteoporotic condition, i.e., the ovariectomized Wistar rat. Two groups of animals, with 3 and 6 months following the induction of the osteoporotic condition were established, and bone tissue properties were compared to age-matched healthy controls. The biomechanical performance of different bones was tested by three-point bending. Structural (load-bearing capacity and stiffness), geometric (cross-sectional area, cortical sectional area, and moment of inertia) and material (modulus of elasticity and maximum elastic stress) properties were also evaluated, while morphological characterization was performed by FEGSEM. The organic content was determined by ash measurements and confocal Raman microscopy was used to evaluate compositional differences. Reported analyses showed that osteoporotic bones presented significant mechanical and morphological differences when compared with those from age-matched controls. Moreover, osteoporotic bones displayed a high ultimate tensile strength and were found to be more brittle than control bones. Attained differences could be related to the reduction in the collagen content, verified in osteoporotic conditions. These results highlight the role of the collagenous component in the structural and material properties of trabecular bone, and may account for the attained reduced bone mass in osteoporotic conditions.por
dc.titleBiomechanical and physicochemical characterization of the rat’s osteoporotic bonepor
degois.publication.title5th International Conference on Mechanics of Biomaterials and Tissuespor
Aparece nas colecções:IPS - ESTS – DEM - Comunicações em congressos

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
abstracts[610379]2.pdf58,79 kBAdobe PDFVer/Abrir

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.