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DemĂȘncia associada ao uso prolongado de inibidores da bomba de protĂ”es
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Abstract(s)
A demĂȘncia, uma condição complexa e debilitante que impacta a função cognitiva e a qualidade de vida, tem suscitado preocupaçÔes quanto Ă sua associação com o uso prolongado de Inibidores da Bomba de ProtĂ”es (IBPs). Estes medicamentos, frequentemente prescritos para tratar condiçÔes como refluxo gastroesofĂĄgico, Ășlcera pĂ©ptica e dispepsia, tĂȘm sido alvo de questionamentos devido ao seu uso em condiçÔes nĂŁo indicadas, podendo apresentar riscos associados ao desenvolvimento de demĂȘncia, especialmente em idosos frequentemente submetidos a polimedicação.
Este estudo visa analisar as teorias propostas sobre a possĂvel relação entre o uso de IBPs e o risco de demĂȘncia. A compreensĂŁo desse cenĂĄrio Ă© crucial para fundamentar decisĂ”es clĂnicas e orientar a prĂĄtica mĂ©dica, proporcionando uma avaliação mais precisa dos benefĂcios e riscos associados a esses medicamentos. Deste modo, a revisĂŁo abrange uma anĂĄlise crĂtica das evidĂȘncias disponĂveis, considerando artigos publicados entre 2015 e 2023, relacionados com o uso prolongado de IBPs e o risco de demĂȘncia.
As evidĂȘncias sobre a associação entre IBPs e demĂȘncia sĂŁo, atĂ© ao momento, inconsistentes.Estudos divergentes indicam um espectro variado de resultados, com algumas anĂĄlises apontando para um aumento no risco, enquanto outras nĂŁo encontram associação significativa. LimitaçÔes nos desenhos dos estudos, tais como tamanhos amostrais reduzidos e a interferĂȘncia de cofatores, impactam a qualidade das conclusĂ”es obtidas. Assim, torna-se imperativo acompanhar de perto os pacientes submetidos a uma terapia crĂłnica com IBPs quanto a possĂveis alteraçÔes na função cognitiva, particularmente em pacientes mais idosos, atĂ© que estudos adicionais possam estabelecer uma relação causal definitiva. AlĂ©m disso, a decisĂŁo de prescrever ou continuar o uso de IBPs deve ser baseada numa avaliação cuidadosa dos benefĂcios e riscos para cada paciente individual, de forma a garantir a segurança e qualidade de vida daqueles que enfrentam os desafios da demĂȘncia.
Dementia, a complex and debilitating condition affecting cognitive function and quality of life, has raised concerns regarding its association with prolonged use of Proton Pump Inhibitors (PPIs). These medications, commonly prescribed for conditions such as gastroesophageal reflux, peptic ulcer, and dyspepsia, have come under scrutiny due to their use in non-indicated conditions, potentially posing risks associated with dementia development, especially in elderly individuals frequently undergoing polypharmacy.This study aims to analyze proposed theories regarding the potential link between PPI use and the risk of dementia. Understanding this scenario is crucial for fundament clinical decisions and guiding medical practice, providing a more accurate assessment of the benefits and risks associated with these medications. Thus, the review encompasses a critical analysis of available evidence, considering articles published between 2015 and 2023, related to the prolonged use of PPIs and the risk of dementia. Evidente regarding the association between PPIs and dementia is, to date, inconsistent. Divergent studies indicate a varied spectrum of results, with some analyses suggesting an increased risk, while others find no significant association. Limitations in study designs, such as small sample sizes and the interference of confounding factors, impact the quality of the conclusions drawn.Therefore, close monitoring of patients undergoing chronic PPI therapy for potential changes in cognitive function, particularly in older patients, becomes imperative until additional studies can establish a definitive causal relationship. Additionally, the decision to prescribe or continue PPI use should be based on a careful assessment of benefits and risks for each individual patient, ensuring the safety and quality of life of those facing the challenges of dementia.
Dementia, a complex and debilitating condition affecting cognitive function and quality of life, has raised concerns regarding its association with prolonged use of Proton Pump Inhibitors (PPIs). These medications, commonly prescribed for conditions such as gastroesophageal reflux, peptic ulcer, and dyspepsia, have come under scrutiny due to their use in non-indicated conditions, potentially posing risks associated with dementia development, especially in elderly individuals frequently undergoing polypharmacy.This study aims to analyze proposed theories regarding the potential link between PPI use and the risk of dementia. Understanding this scenario is crucial for fundament clinical decisions and guiding medical practice, providing a more accurate assessment of the benefits and risks associated with these medications. Thus, the review encompasses a critical analysis of available evidence, considering articles published between 2015 and 2023, related to the prolonged use of PPIs and the risk of dementia. Evidente regarding the association between PPIs and dementia is, to date, inconsistent. Divergent studies indicate a varied spectrum of results, with some analyses suggesting an increased risk, while others find no significant association. Limitations in study designs, such as small sample sizes and the interference of confounding factors, impact the quality of the conclusions drawn.Therefore, close monitoring of patients undergoing chronic PPI therapy for potential changes in cognitive function, particularly in older patients, becomes imperative until additional studies can establish a definitive causal relationship. Additionally, the decision to prescribe or continue PPI use should be based on a careful assessment of benefits and risks for each individual patient, ensuring the safety and quality of life of those facing the challenges of dementia.
Description
Keywords
Inibidores da bomba de protĂ”es Efeitos adversos DemĂȘncia Uso prolongado Proton pump inhibitors Adverse effects Dementia Long-term use