Loading...
Publication
Mastocitoma canino – uma revisão bibliográfica
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 838.51 KB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
Os mastocitomas são frequentemente diagnosticados na prática clínica aplicada a animais de
companhia sendo que representam cerca de 16 a 21% dos tumores cutâneos caninos. O tumor ocorre
habitualmente em animais de estimação mais velhos – altura da vida em que a relação animal-tutor é
geralmente mais forte.
O diagnóstico é efetuado principalmente por citologia e/ou histopatologia, de forma a chegar ao
diagnóstico definitivo e estadiamento clínico/grau histológico. Em animais com mastocitomas de grau
elevado são utilizados exames complementares.
Este artigo de revisão permite facilitar a eleição da terapêutica mais indicada a ser implementada de
acordo com o grau histológico e o tipo de mastocitoma. Os mastocitomas que não apresentam
evidências de metástases como os de grau I e alguns de grau II, a terapêutica de eleição é a excisão
cirúrgica. Mastocitomas que apresentam elevada probabilidade de metastização como os de grau II e
grau III, a cirurgia por si só raramente é curativa, e necessitam de terapia adjuvante com quimioterapia
ou radioterapia. Nos mastocitomas que já apresentam metástases ou são recidivantes o tratamento
será sempre paliativo, que pode passar desde a cirurgia e/ou incluir protocolos de combinação de
quimioterapia.
A opção terapêutica é baseada no tipo de tumor, grau histológico e estadio de desenvolvimento, e pode
passar por cirurgia, radioterapia, quimioterapia, imunoterapia e aplicação de terapias adjuvantes, como
suporte nutricional e gestão da dor. Um resultado satisfatório para todas as partes envolvidas é
altamente dependente de uma boa comunicação entre toda a equipa de saúde e o tutor.
Mastocytomas are frequently diagnosed in clinical practice applied to pets and account for around 16 to 21% of canine skin tumors. Tumor commonly occurs in older pets – the time in life when the pet-tutor relationship is generally strongest. The diagnosis is made mainly by cytology and/or histopathology, in order to reach a definitive diagnosis and clinical staging/histological grade. In animals with high-grade mast cell tumors, complementary exams are used. This review article makes it easier to choose the most appropriate therapy according to the histological grade and type of mastocytoma. Mastocytomas that do not show evidence of metastasis, such as grade I and some grade II mastocytomas, the treatment of choice is surgical excision. Mastocytomas with a high probability of metastasizing, such as grade II and III, surgery alone is rarely curative and requires adjuvant therapy with chemotherapy or radiotherapy. In mastocytomas that have already metastasized or are relapsing, treatment will always be palliative, which may include surgery and/or combination chemotherapy protocols. The therapeutic option is based on the type of tumor, histological grade and stage of development, and may involve surgery, radiotherapy, chemotherapy, immunotherapy and the application of adjuvant therapies, such as nutritional support and pain management. An overwhelming outcome for all parties involved is highly dependent on good communication between the entire healthcare team and the tutor.
Mastocytomas are frequently diagnosed in clinical practice applied to pets and account for around 16 to 21% of canine skin tumors. Tumor commonly occurs in older pets – the time in life when the pet-tutor relationship is generally strongest. The diagnosis is made mainly by cytology and/or histopathology, in order to reach a definitive diagnosis and clinical staging/histological grade. In animals with high-grade mast cell tumors, complementary exams are used. This review article makes it easier to choose the most appropriate therapy according to the histological grade and type of mastocytoma. Mastocytomas that do not show evidence of metastasis, such as grade I and some grade II mastocytomas, the treatment of choice is surgical excision. Mastocytomas with a high probability of metastasizing, such as grade II and III, surgery alone is rarely curative and requires adjuvant therapy with chemotherapy or radiotherapy. In mastocytomas that have already metastasized or are relapsing, treatment will always be palliative, which may include surgery and/or combination chemotherapy protocols. The therapeutic option is based on the type of tumor, histological grade and stage of development, and may involve surgery, radiotherapy, chemotherapy, immunotherapy and the application of adjuvant therapies, such as nutritional support and pain management. An overwhelming outcome for all parties involved is highly dependent on good communication between the entire healthcare team and the tutor.
Description
Keywords
Cães Diagnóstico Estadiamento Mastocitoma Prognóstico Tratamento Diagnosis Dogs Mast cell tumor Prognosis Treatment Staging