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Publication
Utilização do ácido hialurónico no tratamento da doença periodontal
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Advisor(s)
Abstract(s)
Nos últimos anos tem havido um grande aumento no número de investigações científicas sobre a molécula de ácido hialurónico (AH). O ácido hialurónico é um glicosaminoglicano não sulfatado e um importante componente da matriz extracelular. Devido às suas propriedades químicas e biológicas únicas, tem mostrado ter efeitos benéficos no tratamento de patologias em diversas áreas da medicina.
Como consequência das muitas funções atribuídas ao AH, avanços foram feitos no desenvolvimento e aplicação de biomateriais à base de AH no tratamento de várias condições inflamatórias. Portanto, com base nos papéis multifuncionais que o AH tem na cicatrização de feridas em geral, e tendo também em consideração que a cicatrização gengival e óssea seguem princípios biológicos semelhantes, é concebível que a administração de AH em bolsas periodontais possa alcançar efeitos benéficos no tratamento da doença periodontal.
Os estudos consultados na presente revisão bibliográfica revelaram resultados promissores na utilização desta molécula, com grande parte deles a sugerir que o ácido hialurónico tem um efeito benéfico cicatrizante e bacteriostático e a revelarem ainda melhorias nos níveis de IP, IG, PS e NIP em tratamentos periodontais nos quais o ácido hialurónico foi utilizado como coadjuvante.
OBJETIVOS: Esta revisão bibliográfica tem como objetivo apresentar os benefícios da utilização do ácido hialurónico quando usado como coadjuvante no tratamento da doença periodontal.
Foram consultadas as seguintes bases de dados: PubMed, Medline, Scopus, SciELO, Web of Science e Google scholar.
In recent years there has been a great increase in the number of scientific investigations on the hyaluronic acid (HA) molecule. Hyaluronic acid is a glycosaminoglycan and an important component of the extracellular matrix. Due to its unique chemical and biological properties, it has been shown to have beneficial effects in the treatment of pathologies in several areas of medicine. Because of the many roles assigned to HA, advances have been made in the development and application of HA-based biomaterials in the treatment of various inflammatory conditions. Therefore, based on the multifunctional roles that HA plays in wound healing in general, and also taking into account that gingival and bone healing follow similar biological principles, it is conceivable that the administration of HA in periodontal pockets could achieve beneficial effects in the treatment of periodontal disease. The studies consulted in this monograph have revealed promising results in the use of this molecule, with most of them suggesting that hyaluronic acid has a beneficial healing and bacteriostatic effect, with numerous studies showing improvements in PI, GI, PD and CAL levels in periodontal treatments in which hyaluronic acid was used as an adjunct. OBJECTIVES: This bibliographic review aims to present the benefits of using hyaluronic acid when used as an adjunct in the treatment of periodontal disease. The following databases were consulted: PubMed, Medline, Scopus, SciELO, Web of Science and Google scholar.
In recent years there has been a great increase in the number of scientific investigations on the hyaluronic acid (HA) molecule. Hyaluronic acid is a glycosaminoglycan and an important component of the extracellular matrix. Due to its unique chemical and biological properties, it has been shown to have beneficial effects in the treatment of pathologies in several areas of medicine. Because of the many roles assigned to HA, advances have been made in the development and application of HA-based biomaterials in the treatment of various inflammatory conditions. Therefore, based on the multifunctional roles that HA plays in wound healing in general, and also taking into account that gingival and bone healing follow similar biological principles, it is conceivable that the administration of HA in periodontal pockets could achieve beneficial effects in the treatment of periodontal disease. The studies consulted in this monograph have revealed promising results in the use of this molecule, with most of them suggesting that hyaluronic acid has a beneficial healing and bacteriostatic effect, with numerous studies showing improvements in PI, GI, PD and CAL levels in periodontal treatments in which hyaluronic acid was used as an adjunct. OBJECTIVES: This bibliographic review aims to present the benefits of using hyaluronic acid when used as an adjunct in the treatment of periodontal disease. The following databases were consulted: PubMed, Medline, Scopus, SciELO, Web of Science and Google scholar.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Doença periodontal Ácido hialurónico Tratamento periodontal