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Postingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neuron Activity

2020-06-03Journal article Open access
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dc.contributor.authorFernandes, Ana B.
dc.contributor.authorAlves da Silva, Joaquim
dc.contributor.authorAlmeida, Joana
dc.contributor.authorCui, Guohong
dc.contributor.authorGerfen, Charles R.
dc.contributor.authorCosta, Rui M.
dc.contributor.authorOliveira-Maia, Albino J.
dc.date.accessioned2020-11-26T10:53:34Z
dc.date.available2020-12-01T01:30:19Z
dc.date.issued2020-06-03
dc.description.abstractPostingestive nutrient sensing can induce food preferences. However, much less is known about the ability of postingestive signals to modulate food-seeking behaviors. Here we report a causal connection between postingestive sucrose sensing and vagus-mediated dopamine neuron activity in the ventral tegmental area (VTA), supporting food seeking. The activity of VTA dopamine neurons increases significantly after administration of intragastric sucrose, and deletion of the NMDA receptor in these neurons, which affects bursting and plasticity, abolishes lever pressing for postingestive sucrose delivery. Furthermore, lesions of the hepatic branch of the vagus nerve significantly impair postingestive-dependent VTA dopamine neuron activity and food seeking, whereas optogenetic stimulation of left vagus nerve neurons significantly increases VTA dopamine neuron activity. These data establish a necessary role of vagus-mediated dopamine neuron activity in postingestive-dependent food seeking, which is independent of taste signaling.pt_PT
dc.description.sponsorshipEuropean Research Council (ERC) 617142 - NEUROCHUNK
dc.description.sponsorshipNeuron-ERANET - F4T
dc.description.sponsorshipSFRH/BPD/880972/2012
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.neuron.2020.03.009pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/34157
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNeuronpt_PT
dc.subjectAnimalspt_PT
dc.subjectAppetitive Behaviorpt_PT
dc.subjectConditioning, Operantpt_PT
dc.subjectDopaminergic Neuronspt_PT
dc.subjectFoodpt_PT
dc.subjectMicept_PT
dc.subjectMice, Knockoutpt_PT
dc.subjectNon-Nutritive Sweetenerspt_PT
dc.subjectNutritive Sweetenerspt_PT
dc.subjectOptogeneticspt_PT
dc.subjectReinforcement, Psychologypt_PT
dc.subjectStomachpt_PT
dc.subjectSucrosept_PT
dc.subjectTastept_PT
dc.subjectVagus Nervept_PT
dc.subjectVentral Tegmental Areapt_PT
dc.titlePostingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neuron Activitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMED-NEU%2F30845%2F2017/PT
oaire.citation.endPage788.e6pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage778pt_PT
oaire.citation.titleNeuronpt_PT
oaire.citation.volume106pt_PT
oaire.fundingStream9471 - RIDTI
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication8019d8d5-aa5c-42ee-9c67-118923a52841
relation.isProjectOfPublication.latestForDiscovery8019d8d5-aa5c-42ee-9c67-118923a52841

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