Loading...
Publication
Contributions of metabolomic changes associated with obesity in humans and dogs in clinical practice
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 1.6 MB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
A metabolómica é uma área de estudo que se centra na análise de metabolitos em sistemas biológicos
e fornece informações valiosas sobre as alterações metabólicas associadas à obesidade e ao excesso
de peso, tanto em seres humanos como em cães.
Nos seres humanos, os estudos metabolómicos identificaram vários metabolitos-chave que são
influenciados pela obesidade e pelo excesso de peso. Alguns destes metabolitos incluem ácidos
gordos, aminoácidos, triglicéridos e acilcarnitinas. Por outro lado, em cão, verificou-se que metabolitos
semelhantes são influenciados pela obesidade e pelo excesso de peso. No entanto, podem existir
algumas diferenças específicas da espécie no perfil metabolómico. Os cães com obesidade
demonstram frequentemente alterações no metabolismo dos ácidos gordos, incluindo níveis
aumentados de ácidos gordos livres e triglicéridos circulantes. A desregulação dos aminoácidos, como
a elevação dos aminoácidos de cadeia ramificada (do inglês, branched-chain amino-acid, BCAAs),
também foi observada em cães obesos. Além disso, as alterações nos perfis de acilcarnitina e nos
níveis de lisofosfatidilcolinas são comparáveis às observadas nos seres humanos.
É importante notar que os perfis metabolómicos podem variar em função de fatores como a dieta, o
contexto genético e a variação individual. Por conseguinte, é necessário haver mais investigação para
compreender plenamente as alterações metabolómicas associadas à obesidade e ao excesso de peso
em seres humanos e no cão.
Metabolomics is a field of study that focuses on the comprehensive analysis of metabolites in biological systems and provides valuable insights into the metabolic changes associated with obesity and overweight, both in humans and dogs. In humans, metabolomics studies have identified several key metabolites that are influenced by obesity and overweight. Some of these metabolites include fatty acids, amino acids, triglycerides and acylcarnitines. On the other hand, in dogs, similar metabolites have been found to be influenced by obesity and overweight. Nevertheless, there may be some species-specific differences in the metabolomic profile. Dogs with obesity often demonstrate alterations in fatty acid metabolism, including increased levels of circulating free fatty acids and triglycerides. Dysregulation of amino acids, such as elevated branched-chain amino-acid (BCAAs), has also been observed in obese dogs. Additionally, changes in acylcarnitine profiles and lysophosphatidylcholines levels are comparable to those seen in humans. It is important to note that metabolomic profiles can vary depending on factors such as diet, genetic background, and individual variation. Therefore, further research is required to fully understand the metabolomic changes associated with obesity and overweight in humans and dogs.
Metabolomics is a field of study that focuses on the comprehensive analysis of metabolites in biological systems and provides valuable insights into the metabolic changes associated with obesity and overweight, both in humans and dogs. In humans, metabolomics studies have identified several key metabolites that are influenced by obesity and overweight. Some of these metabolites include fatty acids, amino acids, triglycerides and acylcarnitines. On the other hand, in dogs, similar metabolites have been found to be influenced by obesity and overweight. Nevertheless, there may be some species-specific differences in the metabolomic profile. Dogs with obesity often demonstrate alterations in fatty acid metabolism, including increased levels of circulating free fatty acids and triglycerides. Dysregulation of amino acids, such as elevated branched-chain amino-acid (BCAAs), has also been observed in obese dogs. Additionally, changes in acylcarnitine profiles and lysophosphatidylcholines levels are comparable to those seen in humans. It is important to note that metabolomic profiles can vary depending on factors such as diet, genetic background, and individual variation. Therefore, further research is required to fully understand the metabolomic changes associated with obesity and overweight in humans and dogs.
Description
Keywords
Cão Diagnóstico translacional Metabolómica Modelo espontâneo Obesidade Canine Metabolomics Obesity Spontaneous mode Translational diagnostic