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Mastocitoma Intestinal no CĆ£o - Case Report
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Abstract(s)
O mastocitoma canino apresenta-se maioritariamente sobre a forma de massa cutĆ¢nea e/ou
subcutĆ¢nea, no entanto, estĆ£o descritas formas viscerais. O seu quadro clĆnico e prognĆ³stico variam
substancialmente entre animais, localizaĆ§Ć£o anatĆ³mica, grau e estadio da doenƧa.
Os mastocitomas intestinais em cĆ£es estĆ£o ainda pouco descritos, existindo poucas
publicaƧƵes a documentĆ”-los, sendo importante que todos sejam relatados e expostos Ć comunidade
cientĆfica, a fim de melhorar as estratĆ©gias de diagnĆ³stico, tratamento e prognĆ³stico.
O presente caso clĆnico refere-se a uma cadela esterilizada, bulldog francĆŖs, com 8 anos de
idade com histĆ³ria de hematoquezia, sem alteraƧƵes nas anĆ”lises sanguĆneas (hemograma e
bioquĆmicas). Nos exames complementares de imagem (ecografia abdominal, radiografia abdominal,
tomografia computorizada e endoscopia completa) foi possĆvel observar sinais de intussusceĆ§Ć£o Ćleo ceco-cĆ³lica e a identificaĆ§Ć£o de uma massa de grandes dimensƵes ao nĆvel do cĆ³lon. Na endoscopia
gastrointestinal completa foram realizadas biĆ³psias dos diferentes segmentos, incluindo da massa,
contudo estas nĆ£o foram conclusivas.
Como forma de diagnĆ³stico e tratamento, foi realizada enterectomia com remoĆ§Ć£o da massa e
posteriormente avaliaĆ§Ć£o histopatolĆ³gica. O resultado da histopatologia foi compatĆvel com tumor de
cĆ©lulas redondas, sendo que apĆ³s imunohistoquĆmica com o marcador CD117, confirmou-se o
diagnĆ³stico de mastocitoma intestinal. A evoluĆ§Ć£o rĆ”pida dos achados nos controlos ecogrĆ”ficos
realizados (linfonodos reativos de tamanhos diversos, massa mural adjacente Ć anastomose da parede
intestinal e posteriormente aparecimento de uma massa no fĆgado) levaram Ć determinaĆ§Ć£o presuntiva
de uma recidiva local, de metastizaĆ§Ć£o ganglionar e envolvimento hepĆ”tico.
ApĆ³s diagnĆ³stico definitivo e identificaĆ§Ć£o da nova massa no local da anastomose
implementou-se terapia adjuvante com fosfato de toceranib na dose de 3,25 mg/kg. O estado geral do
animal foi piorando e sete semanas e dois dias apĆ³s diagnĆ³stico foi eutanasiado.
Com o presente trabalho pretende-se contribuir para o conhecimento do mastocitoma intestinal
no cĆ£o, bem como retratar a evoluĆ§Ć£o de uma neoplasia ainda pouco reportada em cĆ£es.
Canine mast cell tumour predominantly presents as a cutaneous and/or subcutaneous mass, although visceral forms have also been described. The clinical presentation and prognosis of mast cell tumours vary significantly among animals, anatomical location, grade and stage of the disease. Intestinal mast cell tumors in dogs are still poorly described, with few publications documenting them and it is important that all cases are reported and exposed to the scientific community to improve diagnostic, treatment, and prognostic strategies. The present clinical case refers to an 8-year-old spayed female French Bulldog with a history of hematochezia, with no abnormalities in blood tests (hemogram and biochemistry). Complementary imaging exams (abdominal ultrasound, abdominal radiography, computed tomography and complete endoscopy) revealed signs of ileo-ceco-colic intussusception and the identification of a large mass in the colon. Biopsies were taken from different segments during complete gastrointestinal endoscopy, including the mass, but they were inconclusive. To establish a diagnosis and treatment, enterectomy was performed with mass removal, followed by histopathological evaluation. The histopathology result was consistent with a round cell tumor, and immunohistochemistry with the CD117 marker confirmed the diagnosis of intestinal mast cell tumor. The rapid progression of findings in follow-up ultrasounds (reactive lymph nodes of different sizes, mural mass adjacent to the intestinal wall anastomosis, and subsequently, the appearance of a mass in the liver) led to the presumptive determination of local recurrence, nodal metastasis and hepatic involvement. After a definitive diagnosis and identification of the new mass at the anastomosis site, adjuvant therapy with toceranib phosphate was implemented at a dose of 3.25 mg/kg. However, the animal's overall condition worsened, and seven weeks and two days after the diagnosis, euthanasia was performed. This study aims to contribute to the understanding of intestinal mast cell tumors in dogs and depict the progression of a neoplasm that is still rarely reported in dogs.
Canine mast cell tumour predominantly presents as a cutaneous and/or subcutaneous mass, although visceral forms have also been described. The clinical presentation and prognosis of mast cell tumours vary significantly among animals, anatomical location, grade and stage of the disease. Intestinal mast cell tumors in dogs are still poorly described, with few publications documenting them and it is important that all cases are reported and exposed to the scientific community to improve diagnostic, treatment, and prognostic strategies. The present clinical case refers to an 8-year-old spayed female French Bulldog with a history of hematochezia, with no abnormalities in blood tests (hemogram and biochemistry). Complementary imaging exams (abdominal ultrasound, abdominal radiography, computed tomography and complete endoscopy) revealed signs of ileo-ceco-colic intussusception and the identification of a large mass in the colon. Biopsies were taken from different segments during complete gastrointestinal endoscopy, including the mass, but they were inconclusive. To establish a diagnosis and treatment, enterectomy was performed with mass removal, followed by histopathological evaluation. The histopathology result was consistent with a round cell tumor, and immunohistochemistry with the CD117 marker confirmed the diagnosis of intestinal mast cell tumor. The rapid progression of findings in follow-up ultrasounds (reactive lymph nodes of different sizes, mural mass adjacent to the intestinal wall anastomosis, and subsequently, the appearance of a mass in the liver) led to the presumptive determination of local recurrence, nodal metastasis and hepatic involvement. After a definitive diagnosis and identification of the new mass at the anastomosis site, adjuvant therapy with toceranib phosphate was implemented at a dose of 3.25 mg/kg. However, the animal's overall condition worsened, and seven weeks and two days after the diagnosis, euthanasia was performed. This study aims to contribute to the understanding of intestinal mast cell tumors in dogs and depict the progression of a neoplasm that is still rarely reported in dogs.
Description
Keywords
CĆ£o DiagnĆ³stico Mastocitoma Mastocitoma intestinal PrognĆ³stico Canine Diagnosis Intestinal mast cell tumour Mast cell tumour Prognosis