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Retinopathy of prematurity: A review of pathophysiology and signaling pathways

2022Journal article Open access
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dc.contributor.authorFevereiro-Martins, M
dc.contributor.authorMarques-Neves, C
dc.contributor.authorGuimarães, H
dc.contributor.authorBicho, M
dc.date.accessioned2023-01-03T14:33:44Z
dc.date.available2023-01-03T14:33:44Z
dc.date.issued2022
dc.description.abstractRetinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading cause of visual impairment and childhood blindness worldwide. The disease is characterized by an early stage of retinal microvascular degeneration, followed by neovascularization that can lead to subsequent retinal detachment and permanent visual loss. Several factors play a key role during the different pathological stages of the disease. Oxidative and nitrosative stress and inflammatory processes are important contributors to the early stage of ROP. Nitric oxide synthase and arginase play important roles in ischemia/reperfusion-induced neurovascular degeneration. Destructive neovascularization is driven by mediators of the hypoxia-inducible factor pathway, such as vascular endothelial growth factor and metabolic factors (succinate). The extracellular matrix is involved in hypoxia-induced retinal neovascularization. Vasorepulsive molecules (semaphorin 3A) intervene preventing the revascularization of the avascular zone. This review focuses on current concepts about signaling pathways and their mediators, involved in the pathogenesis of ROP, highlighting new potentially preventive and therapeutic modalities. A better understanding of the intricate molecular mechanisms underlying the pathogenesis of ROP should allow the development of more effective and targeted therapeutic agents to reduce aberrant vasoproliferation and facilitate physiological retinal vascular development.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSurv Ophthalmol. 2022 Nov 23:S0039-6257(22)00169-2.pt_PT
dc.identifier.doi10.1016/j.survophthal.2022.11.007pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/42934
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectRetinopatia da Prematuridadept_PT
dc.subjectNeovascularização Retinianapt_PT
dc.subjectStress Oxidativopt_PT
dc.subjectRecém-Nascido Prematuropt_PT
dc.subjectRetinopathy of Prematuritypt_PT
dc.subjectRetinal Neovascularizationpt_PT
dc.subjectOxidative Stresspt_PT
dc.subjectInfant, Prematurept_PT
dc.titleRetinopathy of prematurity: A review of pathophysiology and signaling pathwayspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleSurvey of Ophthalmologypt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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