Publicação
Efficacy and durability of the association of botox and skinvive in the treatment of moderate/severe wrinkles in the periorbital region : a randomized, controlled, double-blind, split-face clinical study
| datacite.subject.fos | Ciências Médicas::Ciências da Saúde | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Neves, Maria Luiza Boechat Borges | |
| dc.contributor.author | Thome, Cecilia | |
| dc.contributor.author | Silva Junior, Silvio Ventura da | |
| dc.contributor.author | Machado, Thalita | |
| dc.contributor.author | Sánchez-Ayala, Alfonso | |
| dc.contributor.author | Câmara-Souza, Mariana Barbosa | |
| dc.contributor.author | Canales, Giancarlo De la Torre | |
| dc.date.accessioned | 2026-05-07T09:51:09Z | |
| dc.date.available | 2026-05-07T09:51:09Z | |
| dc.date.issued | 2025-08 | |
| dc.description.abstract | Background: The combined efficacy and durability of botulinum toxin A (BTX) and hyaluronic acid fillers (HA) for canthal wrinkles have not been thoroughly evaluated in randomized clinical trials. Aims: This study evaluated the efficacy, safety, and durability of the combined treatment protocol of onabotulinumtoxinA and Juvederm Volite VYC-12 (Skinvive) for moderate and severe canthal lines. Methods: This randomized double-blinded split-face trial included 25 women with periorbital dynamic wrinkles at severity levels II–IV according to the Merz 5-point scale. After bilateral onabotulinummtoxinA injections, the sides of the participants' faces were randomized to receive HA injections or a simulated injection. Assessed variables included electromyography activity (EMG), Merz 5-point crow's feet scale, and FACE-Q appraisal on crow's feet lines. Assessments were performed at baseline, 1, 2, 3, and 6 months. For differences in EMG and satisfaction scores, the two-way repeated measures ANOVA and Bonferroni's post hoc analyses were conducted. Wrinkle severity scores were analyzed with the Mann–Whitney U test. Results: Inter-treatment comparisons revealed no significant differences between treatment protocols in all assessed periods for EMG (p = 0.86). For severity of canthal wrinkles, onabotulinumtoxinA + VYC-12 exhibited lower canthal wrinkle severity in rest and contracted positions after 3 (p = 0.04), and 3 (p = 0.007) and 6 (p = 0.001) months, respectively. Additionally, satisfaction with BTX-HA treatment was significantly higher after 3-month (p = 0.001) and 6-month (p = 0.001) follow-ups compared to BTX treatment. Conclusions: Higher improvements in canthal wrinkles could be enhanced by using onabotulinumtoxinA and VYC-12 in association as a treatment protocol. | eng |
| dc.identifier.citation | M. L. B. B. Neves, C.Thome, S. V. da Silva Junior, et al., “Efficacy and Durability of the Association of Botox and Skinvive in the Treatment of Moderate/Severe Wrinkles in the Periorbital Region: A Randomized, Controlled, Double-Blind, Split-Face Clinical Study,” Journal of Cosmetic Dermatology, 24, no. 8 (2025): e70403, https://doi.org/10.1111/jocd.70403 | |
| dc.identifier.doi | 10.1111/jocd.70403 | |
| dc.identifier.issn | 1473-2165 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/63016 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Wiley | |
| dc.relation.hasversion | https://doi.org/10.1111/jocd.70403 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | botulinum toxin type a | |
| dc.subject | Canthal wrinkles | |
| dc.subject | hyaluronic acid filler | |
| dc.subject | onabotulinumtoxinA | |
| dc.subject | VYC-12 | |
| dc.title | Efficacy and durability of the association of botox and skinvive in the treatment of moderate/severe wrinkles in the periorbital region : a randomized, controlled, double-blind, split-face clinical study | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 8 | |
| oaire.citation.startPage | e70403 | |
| oaire.citation.title | Journal of Cosmetic Dermatology | |
| oaire.citation.volume | 24 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |