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Tumor-Infiltrating T Cells in Skin Basal Cell Carcinomas and Squamous Cell Carcinomas: Global Th1 Preponderance with Th17 Enrichment—A Cross-Sectional Study

2024Artigo científico Acesso aberto
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dc.contributor.authorCunha, D
dc.contributor.authorNeves, M
dc.contributor.authorSilva, D
dc.contributor.authorSilvestre, AR
dc.contributor.authorNunes, PB
dc.contributor.authorArrobas, F
dc.contributor.authorRibot, JC
dc.contributor.authorFerreira, F
dc.contributor.authorMoita, LF
dc.contributor.authorSoares-de-Almeida, L
dc.contributor.authorSilva, JM
dc.contributor.authorFilipe, P
dc.contributor.authorFerreira, J
dc.date.accessioned2024-06-30T21:43:42Z
dc.date.available2024-06-30T21:43:42Z
dc.date.issued2024
dc.description.abstractBasal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are high-incidence, non-melanoma skin cancers (NMSCs). The success of immune-targeted therapies in advanced NMSCs led us to anticipate that NMSCs harbored significant populations of tumor-infiltrating lymphocytes with potential anti-tumor activity. The main aim of this study was to characterize T cells infiltrating NMSCs. Flow cytometry and immunohistochemistry were used to assess, respectively, the proportions and densities of T cell subpopulations in BCCs (n = 118), SCCs (n = 33), and normal skin (NS, n = 30). CD8+ T cells, CD4+ T cell subsets, namely, Th1, Th2, Th17, Th9, and regulatory T cells (Tregs), CD8+ and CD4+ memory T cells, and γδ T cells were compared between NMSCs and NS samples. Remarkably, both BCCs and SCCs featured a significantly higher Th1/Th2 ratio (~four-fold) and an enrichment for Th17 cells. NMSCs also showed a significant enrichment for IFN-γ-producing CD8+T cells, and a depletion of γδ T cells. Using immunohistochemistry, NMSCs featured denser T cell infiltrates (CD4+, CD8+, and Tregs) than NS. Overall, these data favor a Th1-predominant response in BCCs and SCCs, providing support for immune-based treatments in NMSCs. Th17-mediated inflammation may play a role in the progression of NMSCs and thus become a potential therapeutic target in NMSCs.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCells . 2024 Jun 3;13(11):964.pt_PT
dc.identifier.doi10.3390/cells13110964pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/51180
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectCarcinoma Basocelularpt_PT
dc.subjectCarcinoma de Células Escamosaspt_PT
dc.subjectLinfócitos do Interstício Tumoralpt_PT
dc.subjectNeoplasias da Pelept_PT
dc.subjectCélulas Th1pt_PT
dc.subjectCarcinoma, Basal Cellpt_PT
dc.subjectCarcinoma, Squamous Cellpt_PT
dc.subjectLymphocytes, Tumor-Infiltratingpt_PT
dc.subjectSkin Neoplasmspt_PT
dc.subjectTh1 Cellspt_PT
dc.titleTumor-Infiltrating T Cells in Skin Basal Cell Carcinomas and Squamous Cell Carcinomas: Global Th1 Preponderance with Th17 Enrichment—A Cross-Sectional Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.startPage964pt_PT
oaire.citation.titleCellspt_PT
oaire.citation.volume13pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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