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Effectiveness, adherence and safety of home high flow nasal cannula in chronic respiratory disease and respiratory insufficiency : a systematic review

2024-08Contributo em revista Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorJácome, Cristina
dc.contributor.authorJácome, Marta
dc.contributor.authorCorreia, Sara
dc.contributor.authorFlores, Inês
dc.contributor.authorFarinha, Patrícia
dc.contributor.authorDuarte, Mónica
dc.contributor.authorWinck, João Carlos
dc.contributor.authorCatalan, Javier Sayas
dc.contributor.authorLobato, Salvador Díaz
dc.contributor.authorLuján, Manel
dc.contributor.authorCaneiras, Cátia
dc.date.accessioned2026-03-25T15:02:12Z
dc.date.available2026-03-25T15:02:12Z
dc.date.issued2024-08
dc.description.abstractIntroduction: The effectiveness of home high flow nasal cannula (HFNC) for the treatment of chronic respiratory failure in patients with chronic respiratory diseases (CRDs) has not been summarized. We aimed to conduct a systematic review of the effectiveness, adherence, and safety of HFNC in the long-term treatment of patients with chronic respiratory diseases and respiratory failure. Methods: A systematic review was conducted. PubMed, Web of science, and SCOPUS were search up to August 2023. Long-term HFNC studies (≥4 weeks) reporting dyspnea; exacerbations, hospitalizations; peripheral oxygen saturation (SpO2), comfort; patient experience, health-related quality of life or partial pressure of carbon dioxide (paCO2) were included. Results: Thirteen articles (701 patients) based on 10 studies were selected: randomized control trials (n = 3), randomized crossover trials (n = 2), crossover (n = 3) and retrospective (n = 2) studies. COPD (n = 6), bronchiectasis (n = 2), COPD/bronchiectasis (n = 1) and ILD (n = 1) were the underlined CRDs. HFNC reduced exacerbations when compared to usual care/home respiratory therapies (n = 6). Quality of life outcomes were also in favor of HFNC in patients with COPD and bronchiectasis (n = 6). HFNC had significant effects on hospitalizations, paCO2, and lung function. Adherence ranged from 5.2 to 8.6 h/day (n = 5). Three studies reported no events, 3 non-serious events and 2 no differences compared with other home respiratory therapies. Conclusions: HFNC seems more effective than usual care or other home respiratory therapies in reducing exacerbations and improving quality of life in patients with COPD and bronchiectasis, while presenting good adherence and being safe. Its apparently superior effectiveness needs to be better studied in future real-world pragmatic trials.eng
dc.identifier.citationJácome, C., Jácome, M., Correia, S., Flores, I., Farinha, P., Duarte, M., Winck, J. C., Sayas Catalan, J., Díaz Lobato, S., Luján, M., & Caneiras, C. (2024). Effectiveness, Adherence and Safety of Home High Flow Nasal Cannula in Chronic Respiratory Disease and Respiratory Insufficiency: A Systematic Review. Archivos de bronconeumologia, 60(8), 490–502. https://doi.org/10.1016/j.arbres.2024.05.001
dc.identifier.doi10.1016/j.arbres.2024.05.001
dc.identifier.issn1579-2129
dc.identifier.urihttp://hdl.handle.net/10400.26/62440
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpanish Respiratory Society of Pneumology and Thoracic Surgery
dc.relation.hasversionhttps://doi.org/10.1016/j.arbres.2024.05.001
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectChronic obstructive pulmonary disease
dc.subjectHigh-flow cannula
dc.subjectHigh-flow nasal cannula oxygen therapy
dc.subjectHypercapnic
dc.subjectNasal high-flow
dc.subjectPulmonary disease
dc.titleEffectiveness, adherence and safety of home high flow nasal cannula in chronic respiratory disease and respiratory insufficiency : a systematic revieweng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.endPage502
oaire.citation.issue8
oaire.citation.startPage490
oaire.citation.titleArchivos de Bronconeumología
oaire.citation.volume60
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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