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An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals

2018-06-26Journal article Open access
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dc.contributor.authorIigaya, Kiyohito
dc.contributor.authorFonseca, Madalena S.
dc.contributor.authorMurakami, Masayoshi
dc.contributor.authorMainen, Zachary F.
dc.contributor.authorDayan, Peter
dc.date.accessioned2022-02-04T13:11:49Z
dc.date.available2022-02-04T13:11:49Z
dc.date.issued2018-06-26
dc.description.abstractSerotonin has widespread, but computationally obscure, modulatory effects on learning and cognition. Here, we studied the impact of optogenetic stimulation of dorsal raphe serotonin neurons in mice performing a non-stationary, reward-driven decision-making task. Animals showed two distinct choice strategies. Choices after short inter-trial-intervals (ITIs) depended only on the last trial outcome and followed a win-stay-lose-switch pattern. In contrast, choices after long ITIs reflected outcome history over multiple trials, as described by reinforcement learning models. We found that optogenetic stimulation during a trial significantly boosted the rate of learning that occurred due to the outcome of that trial, but these effects were only exhibited on choices after long ITIs. This suggests that serotonin neurons modulate reinforcement learning rates, and that this influence is masked by alternate, unaffected, decision mechanisms. These results provide insight into the role of serotonin in treating psychiatric disorders, particularly its modulation of neural plasticity and learning.pt_PT
dc.description.sponsorshipERC (250334 and 671251)
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1038/s41467-018-04840-2pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/39184
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationINTERNATIONAL NEUROSCIENCE DOCTORAL PROGRAMME INDP - Serotonergic modulation of patient waiting: behavioral and neural mechanisms
dc.relationPREFRONTAL CONTROL OF IMPULSIVE ACTIONS
dc.titleAn effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervalspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleINTERNATIONAL NEUROSCIENCE DOCTORAL PROGRAMME INDP - Serotonergic modulation of patient waiting: behavioral and neural mechanisms
oaire.awardTitlePREFRONTAL CONTROL OF IMPULSIVE ACTIONS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F52446%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/PIDDAC/SFRH%2FBPD%2F46314%2F2008/PT
oaire.citation.startPage2477pt_PT
oaire.citation.titleNature Communicationspt_PT
oaire.citation.volume9pt_PT
oaire.fundingStreamOE
oaire.fundingStreamPIDDAC
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication38461522-4365-49a2-abe2-22a413ccac0e
relation.isProjectOfPublication14d63f82-b06c-4a79-8d14-2db8d2d54f36
relation.isProjectOfPublication.latestForDiscovery38461522-4365-49a2-abe2-22a413ccac0e

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