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MAFLD under the lens: the role of gut microbiota

dc.contributor.authorSousa, Patrícia
dc.contributor.authorMachado, Mariana Verdelho
dc.date.accessioned2023-12-14T22:02:09Z
dc.date.available2023-12-14T22:02:09Z
dc.date.issued2022-09
dc.description.abstractObesity, the metabolic syndrome, and metabolic dysfunction-associated fatty liver disease (MAFLD) can be portrayed as transmissible diseases. Indeed, they can be induced, in animal models, by cohabitation or by transplantation of fecal microbiota from other animals or humans with those diseases. As such, to get a 10,000- foot view, we need to see under the lens the microbes that populate our gut. Gut microbiota participates in the harvesting of energy from nutrients, it allows the digestion of otherwise indigestible nutrients such as fibers, and it also produces short chain fatty acids and some vitamins while emitting different compounds that can regulate whole-body metabolism and elicit proinflammatory responses. The metabolic syndrome and MAFLD share physiopathology and also patterns of gut dysbiota. Moreover, MAFLD also correlates with dysbiota patterns that are associated with direct steatogenic or fibrogenic effects. In the last decade, a tremendous effort has allowed a fair understanding of the dysbiota patterns associated with MAFLD. More recently, research is moving towards the delineation of microbiota-targeted therapies to manage metabolic dysfunction and MAFLD. This review provides in-depth insight into the state-of-the-art of gut dysbiosis in MAFLD, targeting clinical hepatologists.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.20517/mtod.2022.15pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/48496
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectMAFLDpt_PT
dc.subjectgut microbiotapt_PT
dc.subjectobesitypt_PT
dc.subjectdiabetes mellituspt_PT
dc.titleMAFLD under the lens: the role of gut microbiotapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPage14pt_PT
oaire.citation.titleMetabolism and Target Organ Damagept_PT
oaire.citation.volume2pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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