Burkitt's Lymphoma in a pregnant woman: case report and review of the literature

Zagalo, Carlos; Pierdomenico, Francesca; Cabeçadas, José; Santos, Pedro David

http://hdl.handle.net/10400.26/6214

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Authors

Zagalo, Carlos

Pierdomenico, Francesca

Cabeçadas, José

Santos, Pedro David

Abstract(s)

"Burkitt’s lymphoma (BL) is an aggressive B-cellmalignancy with very high proliferation rate,more common inmales than females. Here, we describe a case of Burkitt’s lymphoma in a 24-week pregnant woman with cervical and abdominal involvement. The common genetic event of virtually all BL is a reciprocal chromosomal translocation involving the proto-oncogene MYC and one of the Ig gene heavy or light chain loci. Supportive treatment was administered until early delivery, after which the patient was treated according to protocol LMB96. Pregnancy and tumorogenesis share some important events such as immunologic tolerance, angiogenesis, and editing the host immune response. Little is known about the relationship between these events in pregnancy and in tumorogenesis."