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Earlier initiation of antiretroviral treatment coincides with an initial control of the HIV-1 sub-subtype F1 outbreak among men-having-sex-with-men in Flanders, Belgium

2019-03Contribution to journal Open access
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorVinken, Lore
dc.contributor.authorFransen, Katrien
dc.contributor.authorCuypers, Lize
dc.contributor.authorAlexiev, Ivailo
dc.contributor.authorBalotta, Claudia
dc.contributor.authorDebaisieux, Laurent
dc.contributor.authorSeguin-Devaux, Carole
dc.contributor.authorRibas, Sergio García
dc.contributor.authorGomes, Perpétua
dc.contributor.authorIncardona, Francesca
dc.contributor.authorKaiser, Rolf
dc.contributor.authorRuelle, Jean
dc.contributor.authorSayan, Murat
dc.contributor.authorParaschiv, Simona
dc.contributor.authorParedes, Roger
dc.contributor.authorPeeters, Martine
dc.contributor.authorSönnerborg, Anders
dc.contributor.authorVancutsem, Ellen
dc.contributor.authorVandamme, Anne-Mieke
dc.contributor.authorVan den Wijngaert, Sigi
dc.contributor.authorVan Ranst, Marc
dc.contributor.authorVerhofstede, Chris
dc.contributor.authorStadler, Tanja
dc.contributor.authorLemey, Philippe
dc.contributor.authorVan Laethem, Kristel
dc.date.accessioned2025-07-15T10:57:10Z
dc.date.available2025-07-15T10:57:10Z
dc.date.issued2019-03
dc.description.abstractHuman immunodeficiency virus type 1 (HIV-1) non-B subtype infections occurred in Belgium since the 1980s, mainly amongst migrants and heterosexuals, whereas subtype B predominated in men-having-sex-with-men (MSM). In the last decade, the diagnosis of F1 sub-subtype in particular has increased substantially, which prompted us to perform a detailed reconstruction of its epidemiological history. To this purpose, the Belgian AIDS Reference Laboratories collected HIV-1 pol sequences from all sub-subtype F1-infected patients for whom genotypic drug resistance testing was requested as part of routine clinical follow-up. This data was complemented with HIV-1 pol sequences from countries with a high burden of F1 infections or a potential role in the global origin of sub-subtype F1. The molecular epidemiology of the Belgian subtype F1 epidemic was investigated using Bayesian phylogenetic inference and transmission dynamics were characterized based on birth-death models. F1 sequences were retained from 297 patients diagnosed and linked to care in Belgium between 1988 and 2015. Phylogenetic inference indicated that among the 297 Belgian F1 sequences, 191 belonged to a monophyletic group that mainly contained sequences from people likely infected in Belgium (OR 26.67, 95% CI 9.59–74.15), diagnosed in Flanders (OR 7.28, 95% CI 4.23–12.53), diagnosed at a recent stage of infection (OR 7.19, 95% CI 2.88-17.95) or declared to be MSM (OR 34.8, 95% CI 16.0–75.6). Together with a Spanish clade, this Belgian clade was embedded in the genetic diversity of Brazilian subtype F1 strains and most probably emerged after one or only a few migration events from Brazil to the European continent before 2002. The origin of the Belgian outbreak was dated back to 2002 (95% higher posterior density 2000–2004) and birth-death models suggested that its extensive growth had been controlled (Re < 1) by 2012, coinciding with a time period where delay in antiretroviral treatment initiation substantially declined. In conclusion, phylogenetic reconstruction of the Belgian HIV-1 sub-subtype F1 epidemic illustrates the introduction and substantial dissemination of viral strains in a geographically restricted risk group that was most likely controlled by effective treatment as prevention.eng
dc.identifier.citationVinken L, Fransen K, Cuypers L, Alexiev I, Balotta C, Debaisieux L, Seguin-Devaux C, García Ribas S, Gomes P, Incardona F, Kaiser R, Ruelle J, Sayan M, Paraschiv S, Paredes R, Peeters M, Sönnerborg A, Vancutsem E, Vandamme A-M, Van den Wijngaert S, Van Ranst M, Verhofstede C, Stadler T, Lemey P and Van Laethem K (2019) Earlier Initiation of Antiretroviral Treatment Coincides With an Initial Control of the HIV-1 Sub-Subtype F1 Outbreak Among Men-Having-Sex-With-Men in Flanders, Belgium. Front. Microbiol. 10:613. doi: 10.3389/fmicb.2019.00613
dc.identifier.doi10.3389/fmicb.2019.00613
dc.identifier.issn1664-302X
dc.identifier.urihttp://hdl.handle.net/10400.26/58074
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers
dc.relation.hasversionhttps://doi.org/10.3389/fmicb.2019.00613
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHIV-1 Sub-Subtype F1
dc.subjectBelgium
dc.titleEarlier initiation of antiretroviral treatment coincides with an initial control of the HIV-1 sub-subtype F1 outbreak among men-having-sex-with-men in Flanders, Belgiumeng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.startPage613
oaire.citation.titleFrontiers in Microbiology
oaire.citation.volume10
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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