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MDMA intoxication in a potential organ donor with cardiac arrest

2020-10Journal article Open access
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dc.contributor.authorCastro, André Lobo
dc.contributor.authorTarelho, Sónia
dc.contributor.authorAlmeida, Dina
dc.contributor.authorSousa, Lara
dc.contributor.authorFranco, João
dc.contributor.authorTeixeira, Helena M.
dc.date.accessioned2021-10-21T15:31:29Z
dc.date.available2021-11-01T01:30:31Z
dc.date.issued2020-10
dc.description.abstractAmphetamine and its derivatives’ consumption is still an important public health issue, namely in terms of compounds variability and disposition to consumers. However, some of them, like MDMA, still live in the illicit market, with continuous success. Nevertheless, there is always new information and data on MDMA intoxication, both in vivo and in post-mortem context. The authors report an intoxication case with MDMA, in an 18 years old male, considered a potential organ donor after a cardiac arrest. Whole blood samples were collected in vivo, at the Emergency Room (ER), and post-mortem, at the National Institute of Legal Medicine and Forensic Sciences. After a general screening procedure, samples were extracted by SPE (OASIS® MCX), followed by GC-MS analysis. The whole blood post-mortem sample was positive for lidocaine (< 500 ng/mL), compatible with the ER intervention, and positive for MDMA (2278 ng/mL) and MDA (49 ng/mL), while whole blood samples collected in vivo (during the maintenance of the individual under advanced life support), were positive for MDMA (504 ng/mL to 1918 ng/mL) and MDA (20 ng/mL to 89 ng/mL). Samples were negative for other substances, namely ethanol, other drugs of abuse and medicines.Results interpretation is pivotal to understand the behaviour of the substance. Thus, in this case, MDMA post-mortem behaviour should be carefully evaluated, considering as possible influencers, in the specific context of the case, the time lapse between death verification, maintenance of the advanced life support and body manipulation for organ collection purposes. Also referred and discussed is the ante-mortem/post-mortem ratio of MDMA obtained values, compared with literature references. There is no doubt that death was due to MDMA intoxication, but information from the analysis performed on the in vivo samples suggests that this type of sample should also be considered, in a complementary role, whenever possible.pt_PT
dc.description.versioninfo:eu-repo/semantics/submittedVersionpt_PT
dc.identifier.citationCastro, A. L., Tarelho, S., Almeida, D., Sousa, L., Franco, J. M., & Teixeira, H. M. (2020). MDMA Intoxication in a potential Organ donor with cardiac arrest. Journal of analytical toxicology, 44(8), 923–926pt_PT
dc.identifier.doi10.1093/jat/bkaa042pt_PT
dc.identifier.issn1945-2403
dc.identifier.urihttp://hdl.handle.net/10400.26/37721
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford Academicpt_PT
dc.relation.publisherversionhttps://academic.oup.com/jat/article/44/8/923/5829849pt_PT
dc.subjectMDMApt_PT
dc.subjectOrgan Donorpt_PT
dc.subjectForensic Toxicologypt_PT
dc.subjectSubstance Abuse Detectionpt_PT
dc.subject3,4-Methylenedioxyamphetaminept_PT
dc.titleMDMA intoxication in a potential organ donor with cardiac arrestpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceOxfordpt_PT
oaire.citation.endPage926pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage923pt_PT
oaire.citation.titleJournal of Analytical Toxicologypt_PT
oaire.citation.volume44pt_PT
person.familyNameLobo Castro
person.familyNameTarelho
person.familyNameFranco
person.familyNameTeixeira
person.givenNameAndré
person.givenNameSónia
person.givenNameJoão
person.givenNameHelena M.
person.identifier.ciencia-id4214-85EB-E58C
person.identifier.orcid0000-0002-7258-8523
person.identifier.orcid0000-0001-8366-6702
person.identifier.orcid0000-0002-3268-3841
person.identifier.orcid0000-0001-7570-5521
person.identifier.scopus-author-id7003981256
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication631cbcb7-4c75-4fc1-b4cf-8445d428f1de
relation.isAuthorOfPublication045c4125-1313-445f-b05f-b7f204886052
relation.isAuthorOfPublication04b8f471-69fa-4cc1-942a-7bc7e690a0d4
relation.isAuthorOfPublication.latestForDiscoveryfedcfeb0-e610-4375-aa1e-5ac1fa74cd28

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