Publicação
Revisiting alpha-synuclein pathways to inflammation
| datacite.subject.fos | Ciências Médicas::Ciências da Saúde | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Lyra, Patrícia | |
| dc.contributor.author | Machado, Vanessa | |
| dc.contributor.author | Rota, Silvia | |
| dc.contributor.author | Chaudhuri, Kallol Ray | |
| dc.contributor.author | Botelho, João | |
| dc.contributor.author | Mendes, José João | |
| dc.date.accessioned | 2026-03-11T16:18:20Z | |
| dc.date.available | 2026-03-11T16:18:20Z | |
| dc.date.issued | 2023-04 | |
| dc.description.abstract | Alpha-synuclein (α-Syn) is a short presynaptic protein with an active role on synaptic vesicle traffic and the neurotransmitter release and reuptake cycle. The α-Syn pathology intertwines with the formation of Lewy Bodies (multiprotein intraneuronal aggregations), which, combined with inflammatory events, define various α-synucleinopathies, such as Parkinson’s Disease (PD). In this review, we summarize the current knowledge on α-Syn mechanistic pathways to inflammation, as well as the eventual role of microbial dysbiosis on α-Syn. Furthermore, we explore the possible influence of inflammatory mitigation on α-Syn. In conclusion, and given the rising burden of neurodegenerative disorders, it is pressing to clarify the pathophysiological processes underlying α-synucleinopathies, in order to consider the mitigation of existing low-grade chronic inflammatory states as a potential pathway toward the management and prevention of such conditions, with the aim of starting to search for concrete clinical recommendations in this particular population. | eng |
| dc.identifier.citation | Lyra P, Machado V, Rota S, Chaudhuri KR, Botelho J, Mendes JJ. Revisiting Alpha-Synuclein Pathways to Inflammation. International Journal of Molecular Sciences. 2023; 24(8):7137. https://doi.org/10.3390/ijms24087137 | |
| dc.identifier.doi | 10.3390/ijms24087137 | |
| dc.identifier.issn | 1422-0067 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/62123 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.hasversion | https://doi.org/10.3390/ijms24087137 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | alpha-synuclein | |
| dc.subject | inflammation | |
| dc.subject | neuroinflammation | |
| dc.subject | synucleinopathies | |
| dc.subject | Parkinson’s disease | |
| dc.title | Revisiting alpha-synuclein pathways to inflammation | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 8 | |
| oaire.citation.startPage | 7137 | |
| oaire.citation.title | International Journal of Molecular Sciences | |
| oaire.citation.volume | 24 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |