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High frequency of psychosis in late-stage Parkinson’s disease

2021Journal article Open access
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dc.contributor.authorChendo, Inês
dc.contributor.authorFabbri, Margherita
dc.contributor.authorGodinho, Catarina
dc.contributor.authorSimões, Rita Moiron
dc.contributor.authorSousa, Catarina Severiano
dc.contributor.authorCoelho, Miguel
dc.contributor.authorVoon, Valerie
dc.contributor.authorFerreira, Joaquim J.
dc.date.accessioned2022-04-01T12:58:59Z
dc.date.available2022-04-01T12:58:59Z
dc.date.issued2021
dc.descriptionThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).pt_PT
dc.description.abstractBackground Psychosis is a frequent non-motor symptom in Parkinson’s disease (PD). Estimates of the frequency of Parkinsońs disease psychosis (PDP) vary widely. Knowledge about the frequency and phenomenology of psychosis in late-stage (LS) PD patients is limited. This study aimed to determine the frequency of psychosis in LSPD patients through clinical diagnostic interview (CDI) (gold standard), according to NINDS/NIMH diagnostic criteria for PDP. The secondary objectives were to characterize the phenomenology, to test selected instruments and assess their adequacy in comparison to CDI, and to assess the psychiatric comorbidities.pt_PT
dc.description.abstractMethods A cross-sectional study including LSPD patients (patients with ≥ 7 years from symptoms onset and Hoehn and Yahr scale score > 3 or a Schwab and England scale score < 50% in the ON condition) was conducted. Patients were subjected to psychiatric, neurological, and neuropsychological evaluations. Each patient was interviewed by a psychiatrist who performed a CDI.pt_PT
dc.description.abstractResults 92 LSPD patients were included. 55.4% experienced psychotic symptoms according to NINDS/NIMH diagnostic criteria for PDP. Hallucinations were present in 94.1% and delusions in 29.4% of the psychotic patients. Visual hallucinations were the most common (88.23%) psychotic symptom. 72.5% of LSPD patients with psychotic symptoms had at least one comorbid psychiatric diagnosis. Lower frequency of psychosis was found when the assessment was performed only through selected instruments rather than CDI.pt_PT
dc.description.abstractConclusions A high frequency (55.4%) of psychotic symptoms and comorbid psychiatric (72.5%) diagnosis were found in LSPD patients. The use of CDI, in addition to structured scales may increase the sensitivity of detecting psychotic symptoms.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationnês Chendo, Margherita Fabbri, Catarina Godinho, Rita Moiron Simões, Catarina Severiano Sousa, Miguel Coelho, Valerie Voon, Joaquim J. Ferreira, High frequency of psychosis in late-stage Parkinsońs disease, Clinical Parkinsonism & Related Disorders, 5 (2021) 100119. https://doi.org/10.1016/j.prdoa.2021.100119pt_PT
dc.identifier.doi10.1016/j.prdoa.2021.100119pt_PT
dc.identifier.issn2590-1125
dc.identifier.urihttp://hdl.handle.net/10400.26/40006
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://doi.org/10.1016/j.prdoa.2021.100119pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectParkinson’s diseasept_PT
dc.subjectLate-stagept_PT
dc.subjectPsychosispt_PT
dc.subjectPsychiatric comorbiditiespt_PT
dc.titleHigh frequency of psychosis in late-stage Parkinson’s diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage100119pt_PT
oaire.citation.titleClinical Parkinsonism & Related Disorderspt_PT
oaire.citation.volume5pt_PT
person.familyNameGodinho
person.givenNameCatarina
person.identifierABF-6650-2020
person.identifier.ciencia-id3919-33C7-AAF3
person.identifier.orcid0000-0003-2304-3129
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd399ed41-ae52-47d2-98aa-9de8dce31b05
relation.isAuthorOfPublication.latestForDiscoveryd399ed41-ae52-47d2-98aa-9de8dce31b05

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