Publication
Clinical diagnostic criteria have a high impact on the frequency of dementia in late-stage Parkinson's disease
| datacite.subject.fos | Ciências Médicas | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Sousa, Catarina Severiano e | |
| dc.contributor.author | Fabbri, Margherita | |
| dc.contributor.author | Godinho, Catarina | |
| dc.contributor.author | Simões, Rita | |
| dc.contributor.author | Chendo, Inês | |
| dc.contributor.author | Coelho, Miguel | |
| dc.contributor.author | Martins, Isabel Pavão | |
| dc.contributor.author | Ferreira, Joaquim J. | |
| dc.date.accessioned | 2025-09-16T10:41:43Z | |
| dc.date.available | 2025-09-16T10:41:43Z | |
| dc.date.issued | 2021-05 | |
| dc.description.abstract | Background: Cognitive impairment is a potential late feature of Parkinson's disease (PD). However, studies in patients with late-stage PD are lacking due to the particular characteristics of this population. Objectives: To evaluate the frequency of dementia in late-stage PD patients and to assess the impact of using different diagnostic criteria. Methods: We conducted a cross-sectional study to estimate the frequency of dementia in late-stage PD patients using the International Parkinson and Movement Disorders Society (MDS) (Level II) clinical diagnostic criteria as the primary outcome. We also applied other diagnostic criteria [MDS (Level I), DSM-IV, and DSM-5 criteria] to determine their applicability and impact on dementia frequency. Results: 93 participants with a mean age of 75.8 years (SD 6.8) and 16.5 years (SD 7.5) of disease duration were included. 64.3% were classified as demented using the International Parkinson and Movement Disorders Society (MDS) (Level II) clinical diagnostic criteria. We observed a high discrepancy on the frequency of dementia depending on the criteria applied [6.2% with MDS (Level I), 58.8% with DSM-IV, and 72.0% with DSM-5 criteria]. Conclusions: We found a frequency of dementia below what was observed in similar populations. The particular characteristics of our sample may have contributed as protective factors for late-stage dementia. Dementia frequency varied depending on the criteria used mainly due to the presence of major depression. | eng |
| dc.identifier.citation | Severiano e Sousa C, Fabbri M, Godinho C, Simões R, Chendo I, Coelho M, Martins IP and Ferreira JJ (2021) Clinical Diagnostic Criteria Have a High Impact on the Frequency of Dementia in Late-Stage Parkinson's Disease. Front. Neurol. 12:652424. doi: 10.3389/fneur.2021.652424 | |
| dc.identifier.doi | 10.3389/fneur.2021.652424 | |
| dc.identifier.issn | 1664-2295 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/58674 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Frontiers Media | |
| dc.relation.hasversion | https://doi.org/10.3389/fneur.2021.652424 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Parkinson’s disease | |
| dc.subject | late-stage | |
| dc.subject | dementia | |
| dc.subject | cognitive impairment | |
| dc.subject | diagnostic criteria | |
| dc.title | Clinical diagnostic criteria have a high impact on the frequency of dementia in late-stage Parkinson's disease | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.startPage | 652424 | |
| oaire.citation.title | Frontiers in Neurology | |
| oaire.citation.volume | 12 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |