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HIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed Patients in Portugal Between 2014 and 2019

2022Journal article Open access
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dc.contributor.authorPingarilho, Marta
dc.contributor.authorPimentel, Victor
dc.contributor.authorMiranda, Mafalda N. S.
dc.contributor.authorSilva, Ana Rita
dc.contributor.authorDiniz, António
dc.contributor.authorAscenção, Bianca Branco
dc.contributor.authorPiñeiro, Carmela
dc.contributor.authorKoch, Carmo
dc.contributor.authorRodrigues, Catarina
dc.contributor.authorCaldas, Cátia
dc.contributor.authorMorais, Célia
dc.contributor.authorFaria, Domitília
dc.contributor.authorda Silva, Elisabete Gomes
dc.contributor.authorTeófilo, Eugénio
dc.contributor.authorMonteiro, Fátima
dc.contributor.authorRoxo, Fausto
dc.contributor.authorMaltez, Fernando
dc.contributor.authorRodrigues, Fernando
dc.contributor.authorGaião, Guilhermina
dc.contributor.authorRamos, Helena
dc.contributor.authorCosta, Inês
dc.contributor.authorGermano, Isabel
dc.contributor.authorSimões, Joana
dc.contributor.authorOliveira, Joaquim
dc.contributor.authorFerreira, José
dc.contributor.authorPoças, José
dc.contributor.authorda Cunha, José Saraiva
dc.contributor.authorSoares, Jorge
dc.contributor.authorHenriques, Júlia
dc.contributor.authorMansinho, Kamal
dc.contributor.authorPedro, Liliana
dc.contributor.authorAleixo, Maria João
dc.contributor.authorGonçalves, Maria João
dc.contributor.authorManata, Maria José
dc.contributor.authorMouro, Margarida
dc.contributor.authorSerrado, Margarida
dc.contributor.authorCaixeiro, Micaela
dc.contributor.authorMarques, Nuno
dc.contributor.authorCosta, Olga
dc.contributor.authorPacheco, Patrícia
dc.contributor.authorProença, Paula
dc.contributor.authorRodrigues, Paulo
dc.contributor.authorPinho, Raquel
dc.contributor.authorTavares, Raquel
dc.contributor.authorde Abreu, Ricardo Correia
dc.contributor.authorCôrte-Real, Rita
dc.contributor.authorSerrão, Rosário
dc.contributor.authorCastro, Rui Sarmento e
dc.contributor.authorNunes, Sofia
dc.contributor.authorFaria, Telo
dc.contributor.authorBaptista, Teresa
dc.contributor.authorMartins, Maria Rosário O.
dc.contributor.authorGomes, Perpétua
dc.contributor.authorMendão, Luís
dc.contributor.authorSimões, Daniel
dc.contributor.authorAbecasis, Ana
dc.date.accessioned2024-09-19T12:19:04Z
dc.date.available2024-09-19T12:19:04Z
dc.date.issued2022
dc.description.abstractObjective: To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods: Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were used for subtyping, TDR determination, and transmission cluster (TC) analyses. Results: In Portugal, the overall prevalence of TDR between 2014 and 2019 was 11.0%. TDR presented a decreasing trend from 16.7% in 2014 to 9.2% in 2016 (p for-trend = 0.114). Multivariate analysis indicated that TDR was significantly associated with transmission route (MSM presented a lower probability of presenting TDR when compared to heterosexual contact) and with subtype (subtype C presented significantly more TDR when compared to subtype B). TC analysis corroborated that the heterosexual risk group presented a higher proportion of TDR in TCs when compared to MSMs. Among subtype A1, TDR reached 16.6% in heterosexuals, followed by 14.2% in patients infected with subtype B and 9.4% in patients infected with subtype G. Conclusion: Our molecular epidemiology approach indicates that the HIV-1 epidemic in Portugal is changing among risk group populations, with heterosexuals showing increasing levels of HIV-1 transmission and TDR. Prevention measures for this subpopulation should be reinforced.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fmicb.2022.823208pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/52125
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHarmonizing, Integrating and Vitalizing European Research on hiv/Aids
dc.relationGlobal Health and Tropical Medicine
dc.relationGlobal Health and Tropical Medicine
dc.relationCharacterization of HIV-1 Drug Resistance to Integrase Inhibitors in Portugal: clinical and economic impact for treatment and drug resistance testing guidelines
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHIVpt_PT
dc.subjectDrug resistancept_PT
dc.subjectTransmission clusterspt_PT
dc.titleHIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed Patients in Portugal Between 2014 and 2019pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHarmonizing, Integrating and Vitalizing European Research on hiv/Aids
oaire.awardTitleGlobal Health and Tropical Medicine
oaire.awardTitleGlobal Health and Tropical Medicine
oaire.awardTitleCharacterization of HIV-1 Drug Resistance to Integrase Inhibitors in Portugal: clinical and economic impact for treatment and drug resistance testing guidelines
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/249697/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04413%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04413%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-EPI%2F7066%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-INF%2F31990%2F2017/PT
oaire.citation.titleFrontiers in Microbiologypt_PT
oaire.citation.volume13pt_PT
oaire.fundingStreamFP7
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNamePenim Mendão
person.familyNameSimões
person.givenNameLuís Manuel
person.givenNameDaniel
person.identifierAAW-2241-2021
person.identifier.ciencia-idAA16-B94D-A1A0
person.identifier.ciencia-id1818-7825-CF26
person.identifier.orcid0000-0001-7595-4499
person.identifier.orcid0000-0001-7799-9631
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isProjectOfPublication.latestForDiscovery40294603-c5b6-4fb2-b58b-9a6944ba7665

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