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Systematic review and modelling of Toxoplasma gondii seroprevalence in humans, Europe, 2000 to 2021

2025-08Contributo em revista Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorFriesema, Ingrid H. M.
dc.contributor.authorWaap, Helga
dc.contributor.authorSwart, Arno
dc.contributor.authorGyörke, Adriana
dc.contributor.authorRoux, Delphine Le
dc.contributor.authorEvangelista, Francisco M. D.
dc.contributor.authorSpano, Furio
dc.contributor.authorSchares, Gereon
dc.contributor.authorDeksne, Gunita
dc.contributor.authorGargaté, Maria João
dc.contributor.authorCalero-Bernal, Rafael
dc.contributor.authorJokelainen, Pikka
dc.contributor.authorSeeber, Frank
dc.contributor.authorSroka, Jacek
dc.contributor.authorLundén, Anna
dc.contributor.authorBerg, Oda van den
dc.contributor.authorJore, Solveig
dc.contributor.authorWisselink, Henk J.
dc.contributor.authorDámek, Filip
dc.contributor.authorVestergaard, Lasse S.
dc.contributor.authorOpsteegh, Marieke
dc.date.accessioned2026-05-26T14:44:28Z
dc.date.available2026-05-26T14:44:28Z
dc.date.issued2025-08
dc.description.abstractBackground: Toxoplasma gondii is a zoonotic protozoan capable of infecting warm-blooded animal species and humans. Although toxoplasmosis presents mostly as mild or asymptomatic infection in immunocompetent individuals, in unborn children and people with weakened immune systems, the disease can be severe with ocular, neurological or multi-systemic manifestations and even death. Aim: We aimed to collate and analyse data on T. gondii seroprevalence in humans to model and compare age-dependent prevalence in geographic regions in Europe. Methods: A systematic review identified 1,822 scientific publications, from which seroprevalence data were extracted from 69 studies. Data were analysed using a Bayesian hierarchical model. Results: The modelling of the seroprevalence indicated the highest incidence rates in eastern (50%) and western (48%) Europe, with the lowest estimates in northern Europe (18%) and the United Kingdom (UK) (18%). Eastern and western Europe were regions where T. gondii infections occurred earliest in life, with half of the population expected to be seropositive by the age of 44 and 47 years, respectively. In contrast, in northern Europe and the UK the modelled median time to infection exceeded 170 years. Conclusion: Results of the study provide a robust baseline for future epidemiological research on human T. gondii infections in Europe and may be useful to validate subsequent research, such as risk assessment studies.eng
dc.identifier.citationFriesema Ingrid HM, Waap Helga, Swart Arno, Györke Adriana, Le Roux Delphine, Evangelista Francisco MD, Spano Furio, Schares Gereon, Deksne Gunita, Gargaté Maria João, Calero-Bernal Rafael, Jokelainen Pikka, Seeber Frank, Sroka Jacek, Lundén Anna, van den Berg Oda, Jore Solveig, Wisselink Henk J, Dámek Filip, Vestergaard Lasse S, Opsteegh Marieke. Systematic review and modelling of Toxoplasma gondii seroprevalence in humans, Europe, 2000 to 2021. Euro Surveill. 2025;30(34):pii=2500069. https://doi.org/10.2807/1560-7917.ES.2025.30.34.2500069
dc.identifier.doi10.2807/1560-7917.ES.2025.30.34.2500069
dc.identifier.issn1560-7917
dc.identifier.urihttp://hdl.handle.net/10400.26/63328
dc.language.isoeng
dc.peerreviewedyes
dc.publisherEuropean Centre for Disease Prevention and Control
dc.relation.hasversionhttps://doi.org/10.2807/1560-7917.ES.2025.30.34.2500069
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectToxoplasma gondii
dc.subjectseroprevalence
dc.subjecthumans
dc.subjectEurope
dc.titleSystematic review and modelling of Toxoplasma gondii seroprevalence in humans, Europe, 2000 to 2021eng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.issue34
oaire.citation.startPage2500069
oaire.citation.titleEurosurveillance
oaire.citation.volume30
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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