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Microextraction by Packed Sorbent as a Clean-up Approach for the Determination of Ketamine and Norketamine in Hair by Gas Chromatography-Tandem Mass Spectrometry

2022Journal article Restricted access
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dc.contributor.authorSimão, A Y
dc.contributor.authorOliveira, P
dc.contributor.authorRosendo, L M
dc.contributor.authorRosado, T
dc.contributor.authorAndraus, M
dc.contributor.authorBarroso, Mário
dc.contributor.authorGallardo, E
dc.date.accessioned2023-02-23T14:50:03Z
dc.date.available2023-02-23T14:50:03Z
dc.date.issued2022
dc.description.abstractThe use of new psychoactive substances has been increasing and constitutes a social and public health problem, and hence, toxicological analysis has become of utmost importance for the detection of such substances. In this article, we present the development and full validation of a simple, user and environmentally friendly, cheap and suitable method for the determination of ketamine and its main metabolite norketamine in hair samples. The procedure included using a miniaturized procedure—microextraction by packed sorbent with mixed-mode sorbent—for sample clean-up. Organic solvents use was minimal, and it was possible to obtain a linear method (0.05–10 ng/mg for both analytes). The extraction efficiency ranged from 32 to 61%, which did not impair sensitivity. The method proved to be selective, precise, accurate and suitable for routine analysis for the determination of said compounds in 50-mg hair samples.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationA Y Simão, P Oliveira, L M Rosendo, T Rosado, M Andraus, M Barroso, E Gallardo, Microextraction by Packed Sorbent as a Clean-up Approach for the Determination of Ketamine and Norketamine in Hair by Gas Chromatography-Tandem Mass Spectrometry, Journal of Analytical Toxicology, 2022;, bkac075pt_PT
dc.identifier.doi10.1093/jat/bkac075pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/43934
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.subjectKetaminept_PT
dc.subjectHairpt_PT
dc.subjectGas chromatography-tandem mass spectrometrypt_PT
dc.titleMicroextraction by Packed Sorbent as a Clean-up Approach for the Determination of Ketamine and Norketamine in Hair by Gas Chromatography-Tandem Mass Spectrometrypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/2020.09070.BD/PT
oaire.citation.titleJournal of Analytical Toxicologypt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
person.familyNameBarroso
person.givenNameMário
person.identifier.ciencia-id5110-F476-ECCC
person.identifier.orcid0000-0001-8848-2734
person.identifier.scopus-author-id35329243100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication294b555e-48c4-4013-b981-b8917400c56c
relation.isAuthorOfPublication.latestForDiscovery294b555e-48c4-4013-b981-b8917400c56c
relation.isProjectOfPublication4ca3c3c9-1802-4c7f-8730-9547236896fe
relation.isProjectOfPublication56ce2e5c-35e5-4eb7-8152-2e87e77f638c
relation.isProjectOfPublication496550db-e763-413f-8f4d-e1759a3b7fe2
relation.isProjectOfPublication.latestForDiscovery4ca3c3c9-1802-4c7f-8730-9547236896fe

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