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Dose rate effects on the selective radiosensitization of prostate cells by GRPR-targeted gold nanoparticles

2022-05Contribution to journal Open access
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorMarques, Ana
dc.contributor.authorBelchior, Ana
dc.contributor.authorSilva, Francisco
dc.contributor.authorMarques, Fernanda
dc.contributor.authorCampello, Maria Paula Cabral
dc.contributor.authorPinheiro, Teresa
dc.contributor.authorSantos, Pedro
dc.contributor.authorSantos, Luis
dc.contributor.authorMatos, António P. A.
dc.contributor.authorPaulo, António
dc.date.accessioned2025-11-07T09:44:14Z
dc.date.available2025-11-07T09:44:14Z
dc.date.issued2022-05
dc.description.abstractFor a while, gold nanoparticles (AuNPs) have been recognized as potential radiosensitizers in cancer radiation therapy, mainly due to their physical properties, making them appealing for medical applications. Nevertheless, the performance of AuNPs as radiosensitizers still raises important questions that need further investigation. Searching for selective prostate (PCa) radiosensitizing agents, we studied the radiosensitization capability of the target-specific AuNP-BBN in cancer versus non-cancerous prostate cells, including the evaluation of dose rate effects in comparison with non-targeted counterparts (AuNP-TDOTA). PCa cells were found to exhibit increased AuNP uptake when compared to non-tumoral ones, leading to a significant loss of cellular proliferation ability and complex DNA damage, evidenced by the occurrence of multiple micronucleus per binucleated cell, in the case of PC3 cells irradiated with 2 Gy of γ-rays, after incubation with AuNP-BBN. Remarkably, the treatment of the PC3 cells with AuNP-BBN led to a much stronger influence of the dose rate on the cellular survival upon γ-photon irradiation, as well as on their genomic instability. Overall, AuNP-BBN emerged in this study as a very promising nanotool for the efficient and selective radiosensitization of human prostate cancer PC3 cells, therefore deserving further preclinical evaluation in adequate animal models for prostate cancer radiotherapy.eng
dc.identifier.citationMarques A, Belchior A, Silva F, Marques F, Campello MPC, Pinheiro T, Santos P, Santos L, Matos APA, Paulo A. Dose Rate Effects on the Selective Radiosensitization of Prostate Cells by GRPR-Targeted Gold Nanoparticles. International Journal of Molecular Sciences. 2022; 23(9):5279. https://doi.org/10.3390/ijms23095279
dc.identifier.doi10.3390/ijms23095279
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10400.26/59547
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.hasversionhttps://doi.org/10.3390/ijms23095279
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectradiotherapy
dc.subjectradiosensitizer
dc.subjectgold nanoparticles
dc.subjectprostate cancer
dc.titleDose rate effects on the selective radiosensitization of prostate cells by GRPR-targeted gold nanoparticleseng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.issue9
oaire.citation.startPage5279
oaire.citation.titleInternational Journal of Molecular Sciences
oaire.citation.volume23
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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