Publication
Antimicrobial activity of new green-functionalized oxazoline-based oligomers against clinical isolates
| dc.contributor.author | Martins, Celso | |
| dc.contributor.author | Correia, Vanessa G. | |
| dc.contributor.author | Aguiar-Ricardo, Ana | |
| dc.contributor.author | Cunha, Ângela | |
| dc.contributor.author | Moutinho, Maria Guilhermina M. | |
| dc.date.accessioned | 2016-04-29T08:42:41Z | |
| dc.date.available | 2016-04-29T08:42:41Z | |
| dc.date.issued | 2015-07-28 | |
| dc.description | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | pt_PT |
| dc.description.abstract | "Background: The search for new antimicrobial compounds able to overcome the global issue of microbial resistance to antibiotics is a priority worldwide. Moreover, several commensal microorganisms have been increasingly associated to opportunistic microbial infections. Having previously disclosed the green synthesis and preliminary characterization of the oligomers [linear oligo(ethylenimine) hydrochloride and oligo(2-methyl-2-oxazoline) quaternized with N,Ndimethyldodecylamine] we herein report on the screening of these oligomers against a battery of 69 clinical isolates of Aerococcus spp., Candida spp., Staphylococcus spp. and Streptococcus spp. Findings: The isolates’ susceptibility to both oligomers was evaluated by determining their minimal inhibitory concentration (MIC) and the biocidal effectiveness of each compound was further confirmed through spectrophotometric measurements and fluorescence microscopy. The MIC values of the 69 isolates were highly variable, yet favourably comparable with those of other antimicrobial polymers. The viability assays resulted in 100% of microbial killing rate after only 5 min, highlighting the promising antimicrobial action of these oligomers. Conclusions: Though further studies are required, evidence suggests that a strong effort should be done in order to confirm these compounds as valid alternatives for several clinical applications. This is reinforced by their well described biocompatibility with human tissues and by their proposed mechanism of action which difficult the development of microbial resistance to these compounds." | pt_PT |
| dc.description.sponsorship | This work was partially supported by Fundação para a Ciência e Tecnologia (FCT), Project PTDC/QUI/73939/2006, and by Instituto Superior de Ciências da Saúde Egas Moniz (ISCSEM). | pt_PT |
| dc.identifier.citation | Martins et al. SpringerPlus (2015) 4:382 | pt_PT |
| dc.identifier.doi | 10.1186/s40064-015-1166-5 | pt_PT |
| dc.identifier.issn | 2193-1801 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/13372 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Springer | pt_PT |
| dc.relation | ActivPOL - Development of oxazoline and aziridine-based antimicrobial polymers using supercritical carbon dioxide technology | |
| dc.relation.publisherversion | http://springerplus.springeropen.com/articles/10.1186/s40064-015-1166-5 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Antimicrobial oxazolines | pt_PT |
| dc.subject | Opportunistic pathogens | pt_PT |
| dc.subject | MIC | pt_PT |
| dc.subject | Viability assay | pt_PT |
| dc.subject | Clinical isolates | pt_PT |
| dc.title | Antimicrobial activity of new green-functionalized oxazoline-based oligomers against clinical isolates | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | ActivPOL - Development of oxazoline and aziridine-based antimicrobial polymers using supercritical carbon dioxide technology | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI%2F73939%2F2006/PT | |
| oaire.citation.startPage | 382 | pt_PT |
| oaire.citation.title | SpringerPlus | pt_PT |
| oaire.citation.volume | 4 | pt_PT |
| oaire.fundingStream | 3599-PPCDT | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isProjectOfPublication | 56fb922b-b9fb-499f-80e3-103f86a78468 | |
| relation.isProjectOfPublication.latestForDiscovery | 56fb922b-b9fb-499f-80e3-103f86a78468 |