Logo do repositório
 
Publicação

Primary Antiphospholipid Syndrome Presenting With Life-Threatening Diffuse Alveolar Hemorrhage

2025-10Estudo clínico Acesso aberto
Ver registo simples
dc.contributor.authorCasanova Pinto, J
dc.contributor.authorCosta, MG
dc.contributor.authorFernandes, B
dc.contributor.authorRamalheira, C
dc.date.accessioned2026-01-25T18:39:21Z
dc.date.available2026-01-25T18:39:21Z
dc.date.issued2025-10
dc.description.abstractAntiphospholipid syndrome (APS)-associated diffuse alveolar hemorrhage (DAH) results from antiphospholipid-induced endothelial dysfunction, microvascular thrombosis, and complement activation. Management requires balancing thrombosis prevention and hemorrhage control. High-dose corticosteroids are the first-line therapy. We report a case of a 33-year-old male presenting with progressive dyspnea, hemoptysis, and hypoxemia. Initial evaluation revealed thrombocytopenia, anemia, elevated inflammatory markers, and diffuse bilateral ground-glass opacities on a thoracic computed tomography, consistent with DAH. Autoimmune serology confirmed persistent positivity for lupus anticoagulant, anti-cardiolipin IgM, and anti-β2-glycoprotein-I IgM, fulfilling APS classification criteria. The patient developed respiratory failure, requiring mechanical ventilation and venovenous extracorporeal membrane oxygenation (VV-ECMO). High-dose corticosteroids were initiated, leading to gradual improvement. He was successfully extubated and discharged on long-term anticoagulation with warfarin. At four years of follow-up, he remains free of APS-related complications. This case highlights the importance of recognizing APS as a cause of DAH, particularly in patients with unexplained pulmonary hemorrhage. Early diagnosis and aggressive therapy can improve outcomes.eng
dc.identifier.citationCureus. 2025;17(10):e93814. doi: 10.7759/cureus.93814.
dc.identifier.doi10.7759/cureus.93814
dc.identifier.urihttp://hdl.handle.net/10400.26/61180
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAntiphospholipid Syndrome
dc.subjectDiffuse Alveolar Hemorrhage
dc.titlePrimary Antiphospholipid Syndrome Presenting With Life-Threatening Diffuse Alveolar Hemorrhageeng
dc.typeclinical study
dspace.entity.typePublication
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Casanova-pinto-2025-Primary-antiphospholipid-syndrome-p.pdf
Tamanho:
1.21 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.85 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

HC - MI - Artigos