Logo do repositório
 
Publicação

Fe/57Fe-metallacarboranes with radiosensitizing potential in breast cancer cell models : comparative study between high- (60Co) and low-energy (57Co) gamma radiation sources

2026-02Contributo em revista Acesso aberto
Ver registo simples
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorMaria, Salvatore Di
dc.contributor.authorEngrácia, Diogo M.
dc.contributor.authorPinto, Catarina I. G.
dc.contributor.authorWaerenborgh, João C.
dc.contributor.authorVieira, Bruno J. C.
dc.contributor.authorSantos, Pedro
dc.contributor.authorPinheiro, Teresa
dc.contributor.authorNuez-Martínez, Miquel
dc.contributor.authorMatos, António P.
dc.contributor.authorMendes, Filipa
dc.contributor.authorTeixidor, Francesc
dc.contributor.authorViñas, Clara
dc.contributor.authorMarques, Fernanda
dc.date.accessioned2026-06-08T15:26:03Z
dc.date.available2026-06-08T15:26:03Z
dc.date.issued2026-02
dc.description.abstractBackground: Radiosensitizers can be used to enhance tumor response and mitigate toxicity in healthy tissues during radiation therapy. This study investigates the radiosensitizing potential of the metallacarborane Fe/57Fe-ferrabisdicarbollide in SK-BR-3 and MDA-MB-231 breast cancer cells, using two distinct gamma-photon sources: high-dose 60Co (2.08 Gy) and low-dose 57Co (37.55 mGy, 57Fe Mössbauer effect). Methods: We evaluated cell viability and survival in 2D monolayer and 3D spheroid cultures, as well as the mechanism of cell death (ROS production, apoptosis or necrosis). Computational dosimetry was used to calculate the average absorbed dose. Results: In 2D models, both radiation sources induced reduced viability and increased ROS, with distinct cell death patterns dependent on the source (apoptosis or necrosis). Comparing 2D and 3D MDA-MB-231 models revealed that spheroid survival was significantly more impaired. The low-dose 57Co source caused a significant radiosensitization in MDA-MB-231 spheroids, dramatically impacting viability and survival. This effect is attributed to the Mössbauer effect, where the resonant absorption of 14.41 keV radiation by 57Fe leads to a massive, localized dose enhancement. The subsequent cascade of Auger and conversion electrons (local high LET) caused significantly greater cellular damage than sparse photon radiation. Conclusions: Fe/57Fe-ferrabisdicarbollide demonstrates a potent radiosensitizing effect depending on the cell model and the radiation source used. Crucially, the observed radiosensitization allows for the development of a new, more efficient cancer radiotherapy approach that can achieve therapeutic efficacy using a significantly lower radiation dose to the patient. This paves the way for safer and better-tolerated cancer treatments.eng
dc.identifier.citationDi Maria S, Engrácia DM, Pinto CIG, Waerenborgh JC, Vieira BJC, Santos P, Pinheiro T, Nuez-Martínez M, Matos AP, Mendes F, et al. Fe/57Fe-Metallacarboranes with Radiosensitizing Potential in Breast Cancer Cell Models: Comparative Study Between High- (60Co) and Low-Energy (57Co) Gamma Radiation Sources. Pharmaceutics. 2026; 18(2):214. https://doi.org/10.3390/pharmaceutics18020214
dc.identifier.doi10.3390/pharmaceutics18020214
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/10400.26/63550
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.hasversionhttps://doi.org/10.3390/pharmaceutics18020214
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectboron clusters
dc.subjectferrabisdicarbollide
dc.subjectradiation therapy
dc.subjectmultimodal approaches
dc.subjectradiosensitizers
dc.subjectMössbauer effect
dc.subjectbreast cancer
dc.subjectspheroids
dc.titleFe/57Fe-metallacarboranes with radiosensitizing potential in breast cancer cell models : comparative study between high- (60Co) and low-energy (57Co) gamma radiation sourceseng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.startPage214
oaire.citation.titlePharmaceutics
oaire.citation.volume18
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Artigo_AlvesDeMatos_2026_02.pdf
Tamanho:
3.38 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.85 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

EM - Artigos Científicos