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Optimization of a dispersive liquid–liquid microextraction method followed by UHPLC analysis for fluoxetine quantification in environmental water resources

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dc.contributor.authorRunfola, Massimiliano
dc.contributor.authorLima, Diana L.D.
dc.contributor.authorFonseca, Ana
dc.contributor.authorBarbosa Moreira, Zélia
dc.date.accessioned2022-12-29T11:49:40Z
dc.date.available2022-12-29T11:49:40Z
dc.date.issued2018
dc.description.abstractFluoxetine is the most prescribed drug for treatment of depression. Recently, its presence in aquatic environment has been receiving a growing interest as several studies assessed its effects on aquatic fauna. Therefore, it's important to have an analytical method capable of monitoring these compounds at low concentrations. In this study, a new method was developed based on dispersive liquid–liquid microextraction to preconcentrate fluoxetine in a small volume of water sample (6 mL) before chromatographic analysis using ultra high performance liquid chromatography with fluorescence detection. Effect of composition and volume of extracting mixture, sample pH, vortexing time and salt addition were evaluated. Optimization of extraction conditions lead to an enrichment factor of 61 ± 18. After extraction optimization, recovery percentages of fluoxetine spiked into different water matrices between 83–110% were obtained. For the optimized method, the calibration curve was obtained in the range of 160–2500 ng/L with a limit of detection of 98.9 ng/L and a limit of quantification of 329.8 ng/L.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.doi10.1002/jssc.201800727pt_PT
dc.identifier.issn1615-9314
dc.identifier.urihttp://hdl.handle.net/10400.26/42898
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley-VCHpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectAntidepressantspt_PT
dc.subjectFluoxetinept_PT
dc.subjectMicroextractionpt_PT
dc.subjectwater matrixpt_PT
dc.subjectAntidepressivospt_PT
dc.subjectFluoxetinapt_PT
dc.subjectMicroextraçãopt_PT
dc.titleOptimization of a dispersive liquid–liquid microextraction method followed by UHPLC analysis for fluoxetine quantification in environmental water resourcespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4252pt_PT
oaire.citation.issue23pt_PT
oaire.citation.startPage4246pt_PT
oaire.citation.titleJournal of Separation Sciencept_PT
oaire.citation.volume41pt_PT
person.familyNameGomes Fonseca
person.familyNameBarbosa Moreira
person.givenNameAna Paula
person.givenNameZélia
person.identifier.ciencia-id3C1F-4A0F-8905
person.identifier.ciencia-id5213-E9A1-3FC5
person.identifier.orcid0000-0001-9665-0638
person.identifier.orcid0000-0002-7527-1361
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication62f7e22f-7a99-446e-b2e3-1bf9d19a40a2
relation.isAuthorOfPublication7edc1e73-ebd5-4f58-8574-38a40a4496f5
relation.isAuthorOfPublication.latestForDiscovery62f7e22f-7a99-446e-b2e3-1bf9d19a40a2

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