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Relevant factors for treatment outcome and time to healing in medication-related osteonecrosis of the jaws – A retrospective cohort study

2017-10Journal article Restricted access
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dc.contributor.authorMartins, Ana Silva
dc.contributor.authorCorreia, João André
dc.contributor.authorSalvado, Francisco
dc.contributor.authorCaldas, Cecília
dc.contributor.authorSantos, Nuno
dc.contributor.authorCapelo, António
dc.contributor.authorPalmela, Paulo
dc.date.accessioned2020-07-31T14:05:47Z
dc.date.available2020-07-31T14:05:47Z
dc.date.issued2017-10
dc.description.abstractBackground: Risk factors for medication-related osteonecrosis of the jaw (MRONJ) are well known, although few studies evaluate the factors that influence treatment outcomes in MRONJ and whether discontinuing antiresorptive medication influences healing. Purpose: (1) Describe the characteristics of a population of patients with MRONJ. (2) Identify the factors associated with favourable outcomes. (3) Identify a temporal correlation between discontinuation of antiresorptives and healing time. Methods: A retrospective longitudinal cohort study was carried out, including 77 patients with MRONJ treated between 2004 and 2016. Primary outcome was defined as healed/improved vs. worse/stable. Time to healing was set as the secondary outcome. Statistical significance was defined as p < 0.05. Results: Primary disease, route of administration, lesion location, and development of complications influenced the outcome of treatment. Significant differences in outcomes according to primary disease (p < 0.05) were found when staging, gender, and lesion location were held constant. Time to healing was longer for patients who discontinued medication more than 3 months after diagnosis than for those who discontinued at diagnosis or before - respectively, 36, 9, and 7 months (p = 0.01). Conclusions: The outcome of MRONJ treatment may be influenced by primary disease and route of administration of antiresorptives. Antiresorptive medication discontinuation contributes to reduce healing time in MRONJ.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Craniomaxillofac Surg . 2017 Oct;45(10):1736-1742. doi: 10.1016/j.jcms.2017.07.014pt_PT
dc.identifier.doi10.1016/j.jcms.2017.07.014pt_PT
dc.identifier.issn1010-5182
dc.identifier.urihttp://hdl.handle.net/10400.26/33032
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://doi.org/10.1016/j.jcms.2017.07.014pt_PT
dc.subjectBisphosphonatespt_PT
dc.subjectDenosumabpt_PT
dc.subjectMRONJpt_PT
dc.subjectOsteonecrosispt_PT
dc.subjectSunitinibpt_PT
dc.titleRelevant factors for treatment outcome and time to healing in medication-related osteonecrosis of the jaws – A retrospective cohort studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1742pt_PT
oaire.citation.startPage1736pt_PT
oaire.citation.titleJournal of Cranio-Maxillofacial Surgerypt_PT
oaire.citation.volume45(10)pt_PT
rcaap.embargofctPolítica de copyright do editorpt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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