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Dysarthria in individuals with Parkinson’s disease: a protocol for a binational, cross-sectional, case-controlled study in rrench and european portuguese (FraLusoPark)

2016-10-21Journal article Open access
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dc.contributor.authorPinto, Serge
dc.contributor.authorCardoso, Rita
dc.contributor.authorSadat, Jasmin
dc.contributor.authorGuimarães, Isabel
dc.contributor.authorMercier, Céline
dc.contributor.authorSantos, Helena
dc.contributor.authorAtkinson-Clement, Cyril
dc.contributor.authorCarvalho, Joana
dc.contributor.authorWelby, Pauline
dc.contributor.authorOliveira, Pedro
dc.contributor.authorD’Imperio, Mariapaola
dc.contributor.authorFrota, Sónia
dc.contributor.authorLetanneux, Alban
dc.contributor.authorVigario, Marina
dc.contributor.authorCruz, Marisa
dc.contributor.authorMartins, Isabel Pavão
dc.contributor.authorViallet, François
dc.contributor.authorFerreira, Joaquim
dc.date.accessioned2022-04-01T11:37:42Z
dc.date.available2022-04-01T11:37:42Z
dc.date.issued2016-10-21
dc.description.abstractIntroduction: Individuals with Parkinson’s disease (PD) have to deal with several aspects of voice and speech decline and thus alteration of communication ability during the course of the disease. Among these communication impairments, 3 major challenges include: (1) dysarthria, consisting of orofacial motor dysfunction and dysprosody, which is linked to the neurodegenerative processes; (2) effects of the pharmacological treatment, which vary according to the disease stage; and (3) particular speech modifications that may be language-specific, that is, dependent on the language spoken by the patients. The main objective of the FraLusoPark project is to provide a thorough evaluation of changes in PD speech as a result of pharmacological treatment and disease duration in 2 different languages (French vs European Portuguese). Methods and analysis: Individuals with PD are enrolled in the study in France (N=60) and Portugal (N=60). Their global motor disability and orofacial motor functions is assessed with specific clinical rating scales, without (OFF) and with (ON) pharmacological treatment. 2 groups of 60 healthy age-matched volunteers provide the reference for between-group comparisons. Along with the clinical examinations, several speech tasks are recorded to obtain acoustic and perceptual measures. Patient-reported outcome measures are used to assess the psychosocial impact of dysarthria on quality of life. Ethics and dissemination: The study has been approved by the local responsible committees on human experimentation and is conducted in accordance with the ethical standards. A valuable largescale database of speech recordings and metadata from patients with PD in France and Portugal will be constructed. Results will be disseminated in several articles in peer-reviewed journals and in conference presentations. Recommendations on how to assess speech and voice disorders in individuals with PD to monitor the progression and management of symptoms will be provided.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doidoi:10.1136/bmjopen-2016-012885pt_PT
dc.identifier.issn2044-6055
dc.identifier.urihttp://hdl.handle.net/10400.26/39998
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJpt_PT
dc.subjectDysarthriapt_PT
dc.subjectParkinson’s diseasept_PT
dc.subjectFrenchpt_PT
dc.subjectEuropean portuguesept_PT
dc.titleDysarthria in individuals with Parkinson’s disease: a protocol for a binational, cross-sectional, case-controlled study in rrench and european portuguese (FraLusoPark)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/FCT-ANR%2FNEU-SCC%2F0005%2F2013/PT
oaire.citation.endPage11pt_PT
oaire.citation.issue2016pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleBMJ Openpt_PT
oaire.fundingStream3599-PPCDT
person.familyNamecardoso
person.familyNameGuimarães
person.givenNamerita
person.givenNameIsabel
person.identifier548796
person.identifier.ciencia-idF014-BFD6-49C2
person.identifier.orcid0000-0002-4478-990X
person.identifier.orcid0000-0001-8524-8731
person.identifier.scopus-author-id24586862700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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