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Vascular changes in healthy youngsters with and without influence of oral contraception

2019-12Journal article Open access
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dc.contributor.authorPereira, Anabela
dc.contributor.authorSantos, Helder
dc.contributor.authorPereira, Telmo
dc.contributor.authorConde, Jorge
dc.date.accessioned2020-05-10T20:35:50Z
dc.date.available2020-05-10T20:35:50Z
dc.date.issued2019-12
dc.description.abstractINTRODUCTION: Cardiovascular diseases are one of the leading causes of mortality worldwide. It is known to have a reduced incidence in premenopausal women compared to the opposite sex. This appears to be related to the female hormones and their fluctuation throughout the menstrual cycle. Objectives: To evaluate and correlate behavior patterns of cerebral dynamics and arterial reactivity throughout the menstrual cycle and to identify possible differences caused by the use of oral contraceptives (OC). METHODS: The sample consisted of 21 healthy, eumenorrheic and non-smoking young womens, belonging to the 18-21 age group. There were two distinct groups: 11 in the group without oral contraceptive (SCO) and 10 in the oral contraceptive group (CCO). Both groups performed an evaluation in the menstrual phase (MP), from the 1st to the 4th day, and in the ovulatory phase (OP), from the 12th to the 16th day. The third evaluation was performed in the late luteal phase (LLP) from the 26th to the 30th day, in the SCO group and in the OC pause, from the 21st to the 28th day, in the CCO group. Four noninvasive procedures were performed: blood pressure measurement, axillary temperature, carotid and right brachial artery sonography. RESULTS: There were no statistically significant differences in carotid parameters, however, there were variations in the velocity of the systolic peak (VPS) of the common carotid artery (CCA) and internal carotid artery (ICA) and the ICA resistance index (IR), throughout the cycle. The SCO group showed a significant increase in FMD from MF to OF (p = 0.023), decreasing in LL (p = 0.012). The CCO group demonstrated a relative stabilization of FMD values. In OP, there were statistically significant differences between the two groups in relation to the FMD value (p = 0.040). CONCLUSIONS: Cyclic fluctuations of estrogen appear to influence cerebral vascular impedance and arterial reactivity but in different proportions. In conclusion, this study supports the idea of standardizing the timing of vascular testing in a premenopausal woman.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.17554/j.issn.2309-6861.2019.06.170pt_PT
dc.identifier.issn2312-122X
dc.identifier.urihttp://hdl.handle.net/10400.26/32260
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherACT Publishing Group Limitedpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectEumenorrheicpt_PT
dc.subjectOral contraceptivespt_PT
dc.subjectCarotid arteriespt_PT
dc.subjectFlow-mediated dilatationpt_PT
dc.subjectAnticoncecionais oraispt_PT
dc.subjectArtérias carótidaspt_PT
dc.titleVascular changes in healthy youngsters with and without influence of oral contraceptionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage902pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage804pt_PT
oaire.citation.titleJournal of Cardiology and Therapypt_PT
oaire.citation.volume6pt_PT
person.familyNameDa Conceição Pereira
person.familyNameCosta Santos
person.familyNamePereira
person.familyNameConde
person.givenNameAnabela
person.givenNameHelder Fernando
person.givenNameTelmo
person.givenNameJorge
person.identifierS-9567-2017
person.identifier779139
person.identifier.ciencia-idCF11-1E90-640E
person.identifier.ciencia-id7F18-6CA5-3680
person.identifier.ciencia-idEB19-9F1B-9811
person.identifier.ciencia-id9817-ABCE-36C0
person.identifier.orcid0000-0001-9868-3855
person.identifier.orcid0000-0002-6589-3335
person.identifier.orcid0000-0001-9119-7774
person.identifier.orcid0000-0002-2225-8569
person.identifier.ridM-4626-2013
person.identifier.scopus-author-id55545493500
person.identifier.scopus-author-id24391294200
person.identifier.scopus-author-id55658768000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication987fe26b-1427-409d-b6bd-19161fbc8428
relation.isAuthorOfPublication85969647-47cc-47ee-bec2-1360f30ae958
relation.isAuthorOfPublicationa23d17a5-1427-45f9-9f28-dabc2a3b4345
relation.isAuthorOfPublication.latestForDiscovery987fe26b-1427-409d-b6bd-19161fbc8428

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