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Obesity, acute kidney injury and mortality in patients with sepsis: a cohort analysis

2018Journal article Open access
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dc.contributor.authorGameiro, Joana
dc.contributor.authorGonçalves, Miguel
dc.contributor.authorPereira, Marta
dc.contributor.authorRodrigues, Natacha
dc.contributor.authorGodinho, Iolanda
dc.contributor.authorNeves, Marta
dc.contributor.authorGouveia, João
dc.contributor.authorSilva, Zélia Costa e
dc.contributor.authorJorge, Sofia
dc.contributor.authorLopes, José António
dc.date.accessioned2019-12-06T11:57:47Z
dc.date.available2019-12-06T11:57:47Z
dc.date.issued2018
dc.description.abstractAlthough the prognostic effect of obesity has been studied in critically ill patients its impact on outcomes of septic patients and its role as a risk factor for acute kidney injury (AKI) is not consensual. We aimed to analyze the impact of obesity on the occurrence of AKI and on in-hospital mortality in a cohort of critically ill septic patients. This study is retrospective including 456 adult patients with sepsis admitted to the Division of Intensive Medicine of the Centro Hospitalar Lisboa Norte (Lisbon, Portugal) between January 2008 and December 2014. Obesity was defined as a body mass index of 30 kg/m2 or higher. The Kidney Disease Improving Global Outcomes classification was used to diagnose and classify patients developing AKI. AKI occurred in 87.5% of patients (19.5% with stage 1, 22.6% with stage 2 and 45.4% with stage 3). Obese patients developed AKI more frequently than non-obese patients (92.8% versus 85.5%, p = .035; unadjusted OR 2.2 (95% CI: 1.04-4.6), p = .039; adjusted OR 2.31 (95% CI: 1.07-5.02), p = .034). The percentage of obese patients, however, did not differ between AKI stages (stage 1, 25.1%; stage 2, 28.6%; stage 3, 15.4%; p = .145). There was no association between obesity and mortality (p = .739). Of note, when comparing AKI patients with or without obesity in terms of in-hospital mortality there were also no significant differences between those groups (38.4% versus 38.4%, p = .998). Obesity was associated with the occurrence of AKI in critically ill patients with sepsis; however, it was not associated with in-hospital mortality.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationhttps://doi.org/10.1080/0886022X.2018.1430588pt_PT
dc.identifier.doi10.1080/0886022X.2018.1430588pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/30402
dc.language.isoengpt_PT
dc.publisherTaylor & Francispt_PT
dc.subjectAcute Kidney Injurypt_PT
dc.subjectAgedpt_PT
dc.subjectCritical Illnesspt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectIntensive Care Unitspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectObesitypt_PT
dc.subjectPortugalpt_PT
dc.subjectPrognosispt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectRisk Factorspt_PT
dc.subjectSepsispt_PT
dc.subjectHospital Mortalitypt_PT
dc.titleObesity, acute kidney injury and mortality in patients with sepsis: a cohort analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage126pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage120pt_PT
oaire.citation.titleRenal Failurept_PT
oaire.citation.volume40pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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